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A five year diagnostic follow-up of 1840 patients after a first episode non-schizophrenia and non-affective psychosis
Stockholm University, Faculty of Social Sciences, Centre for Health Equity Studies (CHESS).
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2013 (English)In: Schizophrenia Research, ISSN 0920-9964, E-ISSN 1573-2509, Vol. 150, no 1, 205-210 p.Article in journal (Refereed) Published
Abstract [en]

Objective

It is not clear which patients with a first psychotic episode will develop schizophrenia. We performed a diagnostic follow-up of patients treated for a first time non-affective, non-schizophrenia psychosis and explored potential predictors of a subsequent schizophrenia or schizoaffective diagnosis.

Methods

This register-based cohort study comprises individuals born between 1973 and 1978 in Sweden, with a first hospital-treated psychosis excluding schizophrenia, schizoaffective disorder, bipolar disorder and depressive disorder with psychotic symptoms (n = 1840). The patients were followed for five years regarding subsequent diagnoses. Psychiatric, social, family history of psychiatric illness, premorbid intellectual level, head injuries and obstetrical complications were investigated by logistic regression as predictors of schizophrenia or schizoaffective diagnosis.

Results

During the follow-up, 18% were diagnosed with schizophrenia or schizoaffective disorder, 5% were diagnosed with bipolar disorder, whereas 29% were not re-admitted to a psychiatric clinic. Patients with a first-degree relative hospitalized for schizophrenia and/or bipolar disorder had an increased risk of subsequent diagnosis for schizophrenia or schizoaffective disorder (odds ratio 1.9 and 95% confidence interval 1.1 to 3.0)), whereas previous severe criminality was associated with a decreased risk (odds ratio 0.5, 95% confidence interval 0.3–0.8).

Conclusion

Diagnostic outcome was diverse after a first non-schizophrenia and non-affective psychosis. Family history of severe mental illness and no previous conviction for severe criminality were the strongest risk factors for a future schizophrenia or schizoaffective diagnosis.

Place, publisher, year, edition, pages
2013. Vol. 150, no 1, 205-210 p.
National Category
Psychiatry
Identifiers
URN: urn:nbn:se:su:diva-92947DOI: 10.1016/j.schres.2013.07.011ISI: 000324294700034PubMedID: 23899998OAI: oai:DiVA.org:su-92947DiVA: diva2:643278
Note

AuthorCount: 5;

Funding Agency:

Marta and Nicke Nasvell Foundation 

Available from: 2013-08-26 Created: 2013-08-26 Last updated: 2017-12-06Bibliographically approved

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CiteExportLink to record
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