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The Drosophila clotting system and its messages for mammals
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
2014 (English)In: Developmental and Comparative Immunology, ISSN 0145-305X, E-ISSN 1879-0089, Vol. 42, no 1, 42-46 p.Article in journal (Refereed) Published
Abstract [en]

Drosophila has been increasingly used as a model to study hemolymph clotting. Proteomics and bioinformatics identified candidate clotting-factors, several of which were tested using genetics. Mutants and lines with reduced expression of clotting-factors show subtle effects after wounding, indicating that sealing wounds may rely on redundant mechanisms. More striking effects are observed after infection, in particular when a natural infection model involving entomopathogenic nematodes is used. When translated into mammalian models these results reveal that mammalian blood clots serve a similar immune function, thus providing a new example of the usefulness of studying invertebrate models.

Place, publisher, year, edition, pages
2014. Vol. 42, no 1, 42-46 p.
Keyword [en]
Insect immunity, Innate immunity, Transglutaminase, Phenoloxidase
National Category
Immunology Zoology
Identifiers
URN: urn:nbn:se:su:diva-93057DOI: 10.1016/j.dci.2013.03.014ISI: 000328174200006PubMedID: 23545286OAI: oai:DiVA.org:su-93057DiVA: diva2:644392
Available from: 2013-08-30 Created: 2013-08-30 Last updated: 2017-12-06Bibliographically approved

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Theopold, UlrichKrautz, Robert
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