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Screening and determination of drugs in human saliva utilizing microextraction by packed sorbent and liquid chromatography-tandem mass spectrometry
Stockholm University, Faculty of Science, Department of Analytical Chemistry.
Stockholm University, Faculty of Science, Department of Analytical Chemistry.
2013 (English)In: BMC Biomedical chromotography, ISSN 0269-3879, E-ISSN 1099-0801, Vol. 27, no 9, 1188-1191 p.Article in journal (Refereed) Published
Abstract [en]

This study presents a new method for collecting and handling saliva samples using an automated analytical microsyringe and microextraction by packed syringe (MEPS). The screening and determination of lidocaine in human saliva samples utilizing MEPS and liquid chromatography-tandem mass spectrometry (LC-MS/MS) were carried out. An exact volume of saliva could be collected. The MEPS C-8-cartridge could be used for 50 extractions before it was discarded. The extraction recovery was about 60%. The pharmacokinetic curve of lidocaine in saliva using MEPS-LC-MS/MS is reported.

Place, publisher, year, edition, pages
2013. Vol. 27, no 9, 1188-1191 p.
Keyword [en]
eVol, MEPS, LC-MS/MS, lidocaine, saliva samples
National Category
Biochemistry and Molecular Biology Pharmacology and Toxicology Analytical Chemistry
Identifiers
URN: urn:nbn:se:su:diva-93554DOI: 10.1002/bmc.2925ISI: 000322717100015OAI: oai:DiVA.org:su-93554DiVA: diva2:647717
Note

AuthorCount:2;

Available from: 2013-09-12 Created: 2013-09-10 Last updated: 2017-12-06Bibliographically approved

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Abdel Rehim, Mohamed
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