Antibodies to the Plasmodiumfalciparum antigen Pf332 cooperated with human monocytes inhibit parasitegrowth by inducing intraerythrocytic abnormal parasite forms in vitro
(English)Manuscript (preprint) (Other academic)
IntraerythrocyticPlasmodium parasite proliferation istightly related to disease seriousness. Intraerythrocytic parasite developmentis fundamental to the proliferation of the malaria parasite which is affectedby many factors. Antibodies inhibiting intraerythrocytic parasite growth ordevelopment have been long indicated in protective immune mechanisms,particularly in cooperation with human monocytes. Here, we show that the developmentP. falciparum intraerythrocyticparasite was significantly disturbed by antibodies reactive with theintraerythrocytic parasitic antigen Pf332 by inducing parasites with anabnormal morphology. A synergistic effect in the induction of the abnormal formswas seen when antibodies cooperated with human monocytes. The long period of 48hours intraerythrocytic development provides a greater opportunity for antibodiesto react with the intraerythrocytic antigens than with merozoite stage antigens,which are exposed only for a short period of time.
IdentifiersURN: urn:nbn:se:su:diva-93781OAI: oai:DiVA.org:su-93781DiVA: diva2:648472