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Antibodies to the Plasmodiumfalciparum antigen Pf332 cooperated with human monocytes inhibit parasitegrowth by inducing intraerythrocytic abnormal parasite forms in vitro
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
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(English)Manuscript (preprint) (Other academic)
Abstract [en]

IntraerythrocyticPlasmodium parasite proliferation istightly related to disease seriousness. Intraerythrocytic parasite developmentis fundamental to the proliferation of the malaria parasite which is affectedby many factors. Antibodies inhibiting intraerythrocytic parasite growth ordevelopment have been long indicated in protective immune mechanisms,particularly in cooperation with human monocytes. Here, we show that the developmentP. falciparum intraerythrocyticparasite was significantly disturbed by antibodies reactive with theintraerythrocytic parasitic antigen Pf332 by inducing parasites with anabnormal morphology. A synergistic effect in the induction of the abnormal formswas seen when antibodies cooperated with human monocytes. The long period of 48hours intraerythrocytic development provides a greater opportunity for antibodiesto react with the intraerythrocytic antigens than with merozoite stage antigens,which are exposed only for a short period of time.

National Category
Immunology
Identifiers
URN: urn:nbn:se:su:diva-93781OAI: oai:DiVA.org:su-93781DiVA: diva2:648472
Available from: 2013-09-16 Created: 2013-09-16 Last updated: 2013-09-16Bibliographically approved
In thesis
1. Studies on malaria blood stage infection and host responses
Open this publication in new window or tab >>Studies on malaria blood stage infection and host responses
2013 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The challenges in controlling malaria infectious disease are increasing due to drug resistance and incomplete immunity induced by malaria infection. Moreover there is no effective vaccine available against malaria blood stage infection. Fortunately the completions of the genomic sequences of several Plasmodium species and their bioinformatic analyses have revealed gene homologies indicating the considerable homologies between the human parasite P. falciparum and the mouse parasite P. yoelii. We investigated intensively the presence of functionally and antigenically conserved domains between P. falciparum and P. yoelii at asexual blood-stages. We took advantage of P. yoelii infection to study malaria anemia in a mouse malaria model that focused on cytokines and the cells producing them. Moreover, we explored antibodies reactive with the intraerythrocytic parasite antigen Pf332 for their effect on parasite growth in vitro in cooperation with human monocytes. Taken together, the whole study unlocks a few windows of malaria infection in host responses and we may need to change our strategies in fighting against malaria parasites by enlarging our scope of choosing components as vaccine candidates to control the disease. 

Place, publisher, year, edition, pages
Stockholm: Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 2013. 80 p.
Keyword
Malaria, cytokines, parasite ligands, merozoite released soluble proteins (MRSPs)
National Category
Immunology
Research subject
Molecular Biosciences
Identifiers
urn:nbn:se:su:diva-93732 (URN)978-91-7447-761-0 (ISBN)
Public defence
2013-10-10, Ahlmannsalen, Geovetenskapens hus, Svante Arrhenius väg 12, Stockholm, 10:00 (English)
Opponent
Supervisors
Projects
Malaria, cytokines, parasite ligands, merozoite released soluble proteins (MRSPs)
Note

At the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 3: Manuscript.

Available from: 2013-09-18 Created: 2013-09-13 Last updated: 2013-09-19Bibliographically approved

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CiteExportLink to record
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