Cognitive outcome in adolescents and young adults after repeat courses of antenatal corticosteroids
2013 (English)In: Journal of Pediatrics, ISSN 0022-3476, E-ISSN 1097-6833, Vol. 163, no 2, 441-446 p.Article in journal (Refereed) Published
Objective To investigate whether repeat courses of antenatal corticosteroids have long-term effects on cognitive and psychological functioning. Study design In a prospective cohort study, 58 adolescents and young adults (36 males) who had been exposed to 2-9 weekly courses of betamethasone in utero were assessed with neuropsychological tests and behavior self-reports. Unexposed subjects (n = 44, 25 males) matched for age, sex, and gestational age at birth served as a comparison group. In addition, individuals exposed in utero to a single course (n = 25, 14 males) were included for dose-response analysis. Group differences were investigated using multilevel linear modeling. Results Mean scores obtained in 2 measures of attention and speed were significantly lower in subjects exposed to 2 or more antenatal corticosteroids courses (Symbol Search, P = .009; Digit Span Forward, P = .02), but these were not dose-dependent. Exposure to repeat courses of antenatal corticosteroids was not associated with general deficits in higher cognitive functions, self-reported attention, adaptability, or overall psychological function. Conclusions Although this study indicates that repeat exposure to antenatal corticosteroids may have an impact on aspects of executive functioning, it does not provide support for the prevailing concern that such fetal exposure will have a major adverse impact on cognitive functions and psychological health later in life.
Place, publisher, year, edition, pages
2013. Vol. 163, no 2, 441-446 p.
WAIS, Wechsler Adult Intelligence Scale, WISC, Wechsler Intelligence Scale for Children
Research subject Psychology
IdentifiersURN: urn:nbn:se:su:diva-94190DOI: 10.1016/j.jpeds.2013.01.030ISI: 000322959500029OAI: oai:DiVA.org:su-94190DiVA: diva2:652483