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Perceived Stress at Work Is Associated with Lower Levels of DHEA-S
Stockholm University, Faculty of Social Sciences, Stress Research Institute. (Epidemiologi)
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2013 (English)In: PLoS ONE, ISSN 1932-6203, Vol. 8, no 8, e72460- p.Article in journal (Refereed) Published
Abstract [en]

Background: It is known that long-term psychosocial stress may cause or contribute to different diseases and symptoms and accelerate aging. One of the consequences of prolonged psychosocial stress may be a negative effect on the levels of dehydroepiandrosterone (DHEA) and its sulphated metabolite dehydroepiandrosterone sulphate (DHEA-S). The aim of this study is to investigate whether levels of DHEA and DHEA-S differ in individuals who report perceived stress at work compared to individuals who report no perceived stress at work. Methods: Morning fasting DHEA-S and DHEA levels were measured in serum in a non-stressed group (n = 40) and a stressed group (n = 41). DHEA and DHEA-S levels were compared between the groups using ANCOVA, controlling for age. Results: The mean DHEA-S levels were 23% lower in the subjects who reported stress at work compared to the non-stressed group. Statistical analysis (ANCOVA) showed a significant difference in DHEA-S levels between the groups (p = 0.010). There was no difference in DHEA level between the groups. Conclusions: This study indicates that stressed individual have markedly lower levels of DHEA-S. Given the important and beneficial functions of DHEA and DHEA-S, lower levels of DHEA-S may constitute one link between psychosocial stress, ill health and accelerated ageing.

Place, publisher, year, edition, pages
2013. Vol. 8, no 8, e72460- p.
National Category
Natural Sciences Engineering and Technology
URN: urn:nbn:se:su:diva-94187DOI: 10.1371/journal.pone.0072460ISI: 000323733800055Local ID: P2930OAI: diva2:652563


Funding Agencies:

Swedish government

Funding Agency:

Swedish Government

Available from: 2013-10-01 Created: 2013-09-30 Last updated: 2013-11-12Bibliographically approved

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