The hepatitis B x antigen anti-apoptotic effector URG7 is localized to the endoplasmic reticulum membrane
2013 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 587, no 18, 3058-3062 p.Article in journal (Refereed) Published
Hepatitis B x antigen up-regulates the liver expression of URG7 that contributes to sustain chronic virus infection and to increase the risk for hepatocellular carcinoma by its anti-apoptotic activity. We have investigated the subcellular localization of URG7 expressed in HepG2 cells and determined its membrane topology by glycosylation mapping in vitro. The results demonstrate that URG7 is N-glycosylated and located to the endoplasmic reticulum membrane with an N-lumen-C-cytosol orientation. The results imply that the anti-apoptotic effect of URG7 could arise from the C-terminal cytosolic tail binding a pro-apoptotic signaling factor and retaining it to the endoplasmic reticulum membrane.
Place, publisher, year, edition, pages
2013. Vol. 587, no 18, 3058-3062 p.
URG7, Hepatitis B x antigen, Apoptosis, Cellular localization, Topology, Endoplasmic reticulum
Biochemistry and Molecular Biology Biophysics Cell Biology
IdentifiersURN: urn:nbn:se:su:diva-94175DOI: 10.1016/j.febslet.2013.07.042ISI: 000324033700026OAI: oai:DiVA.org:su-94175DiVA: diva2:652628
Swedish Cancer Society; Swedish Foundation for Strategic Research 2013-10-012013-09-302015-01-30Bibliographically approved