Enantioselective Dehydrochlorination of δ-Hexachlorocyclohexane and δ-Pentachlorocyclohexene by LinA1 and LinA2 from Sphingobium indicum B90A
2013 (English)In: Applied and Environmental Microbiology, ISSN 0099-2240, E-ISSN 1098-5336, Vol. 79, no 19, 6180-6183 p.Article in journal (Refereed) Published
ÎŽ-Hexachlorocyclohexane (ÎŽ-HCH), one of the prevalent isomers of technical HCH, was enantioselectively dehydrochlorinated by the dehydrochlorinases LinA1 and LinA2 from Sphingobium indicum B90A to the very same ÎŽ-pentachlorocyclohexene enantiomer. Racemic ÎŽ-pentachlorocyclohexene, however, was transformed with opposite enantioselectivities by the two enzymes. A transformation pathway based on an anti-1,2-elimination, followed by a syn-1,4-elimination and a subsequent syn-1,2-elimination is postulated.
Place, publisher, year, edition, pages
2013. Vol. 79, no 19, 6180-6183 p.
IdentifiersURN: urn:nbn:se:su:diva-94607DOI: 10.1128/AEM.01770-13PubMedID: 23872559OAI: oai:DiVA.org:su-94607DiVA: diva2:653990