Direct Catalytic Asymmetric Synthesis of Pyrazolidine Derivatives
2012 (English)In: ChemistryOpen, ISSN 2191-1363, Vol. 1, no 3, 134-139 p.Article in journal (Refereed) Published
A highly enantioselective, metal-free cascade reaction between di-1,2-N-protected hydrazine and α,β-unsaturated aldehydes is disclosed. The catalytic, asymmetric cascade transformation is a direct entry to 3-hydroxypyrazolidine and 3-allylpyrazolidine derivatives in one step and two steps, respectively, with >19:1 d.r. and 98–99 % ee using simple chiral pyrrolidines as catalysts.
Place, publisher, year, edition, pages
2012. Vol. 1, no 3, 134-139 p.
1, 4-selectivity, asymmetric catalysis, cascade reactions, hemiaminals, metal-free catalysis, pyrazolidines
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-94675DOI: 10.1002/open.201200015OAI: oai:DiVA.org:su-94675DiVA: diva2:654792