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Interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
2013 (English)In: Scientific Reports, ISSN 2045-2322, E-ISSN 2045-2322, Vol. 3, 2608- p.Article in journal (Refereed) Published
Abstract [en]

Recent experiments have revealed that some membrane proteins aggregate to form clusters. This type of process has been proven to be dynamic and to be actively maintained by external kinetics. Additionally, this dynamic recruiting is cholesterol- and actin-dependent, suggesting that raft organization and cytoskeleton rearrangement play a crucial role. In the present study, we propose a simple model that provides a general framework to describe the dynamical behavior of lipid-protein assemblies. Our results suggest that lipid-mediated interactions and cytoskeleton-anchored proteins contribute to the modulation of such behavior. In particular, we find a resonant condition between the membrane protein and cytoskeleton dynamics that results in the invariance of the ratio of clustered proteins that is found in in vivo experimental observations.

Place, publisher, year, edition, pages
2013. Vol. 3, 2608- p.
National Category
Natural Sciences Engineering and Technology
Identifiers
URN: urn:nbn:se:su:diva-94734DOI: 10.1038/srep02608ISI: 000324090000001OAI: oai:DiVA.org:su-94734DiVA: diva2:655117
Note

AuthorCount:3;

Funding Agencies:

SEID BFU2010-21847-C02; DURSI 2009-SGR-1055 

Available from: 2013-10-10 Created: 2013-10-09 Last updated: 2017-12-06Bibliographically approved

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