Change search
ReferencesLink to record
Permanent link

Direct link
Interplay of cytoskeletal activity and lipid phase stability in dynamic protein recruitment and clustering
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics.
2013 (English)In: Scientific Reports, ISSN 2045-2322, Vol. 3, 2608- p.Article in journal (Refereed) Published
Abstract [en]

Recent experiments have revealed that some membrane proteins aggregate to form clusters. This type of process has been proven to be dynamic and to be actively maintained by external kinetics. Additionally, this dynamic recruiting is cholesterol- and actin-dependent, suggesting that raft organization and cytoskeleton rearrangement play a crucial role. In the present study, we propose a simple model that provides a general framework to describe the dynamical behavior of lipid-protein assemblies. Our results suggest that lipid-mediated interactions and cytoskeleton-anchored proteins contribute to the modulation of such behavior. In particular, we find a resonant condition between the membrane protein and cytoskeleton dynamics that results in the invariance of the ratio of clustered proteins that is found in in vivo experimental observations.

Place, publisher, year, edition, pages
2013. Vol. 3, 2608- p.
National Category
Natural Sciences Engineering and Technology
URN: urn:nbn:se:su:diva-94734DOI: 10.1038/srep02608ISI: 000324090000001OAI: diva2:655117


Funding Agencies:

SEID BFU2010-21847-C02; DURSI 2009-SGR-1055 

Available from: 2013-10-10 Created: 2013-10-09 Last updated: 2013-10-10Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Gomez Llobregat, Jordi
By organisation
Department of Biochemistry and Biophysics
In the same journal
Scientific Reports
Natural SciencesEngineering and Technology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 14 hits
ReferencesLink to record
Permanent link

Direct link