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Dopamine D1 receptors and age differences in brain activation during working memory
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Stockholm University, Faculty of Social Sciences, Department of Psychology.
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2011 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 32, no 10, 1849-1856 p.Article in journal (Refereed) Published
Abstract [en]

In an fMRI study, 20 younger and 20 healthy older adults were scanned while performing a spatial working-memory task under two levels of load. On a separate occasion, the same subjects underwent PET measurements using the radioligand [11C] SCH23390 to determine dopamine D1 receptor binding potential (BP) in caudate nucleus and dorsolateral prefrontal cortex (DLPFC). The fMRI study revealed a significant load modulation of brain activity (higher load > lower load) in frontal and parietal regions for younger, but not older, adults. The PET measurements showed marked age-related reductions of D1 BP in caudate and DLPFC. Statistical control of caudate and DLPFC D1 binding eliminated the age-related reduction in load-dependent BOLD signal in left frontal cortex, and attenuated greatly the reduction in right frontal and left parietal cortex. These findings suggest that age-related alterations in dopaminergic neurotransmission may contribute to underrecruitment of task-relevant brain regions during working-memory performance in old age.

Place, publisher, year, edition, pages
Fayetteville, N.Y: Ankho International , 2011. Vol. 32, no 10, 1849-1856 p.
Keyword [en]
Aging; Dopamine; D1 receptors; fMRI; Load-dependent BOLD response; Multimodal brain imaging; PET; Spatial working memory
National Category
Psychology
Identifiers
URN: urn:nbn:se:su:diva-94949OAI: oai:DiVA.org:su-94949DiVA: diva2:657119
Available from: 2013-10-18 Created: 2013-10-18 Last updated: 2017-12-06Bibliographically approved

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Fischer, Håkan
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