Change search
ReferencesLink to record
Permanent link

Direct link
Powerful GC-TOF-MS Techniques for Screening, Identification and Quantification of Halogenated Natural Products
Umeå universitet.
Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
Leco Corporation.
Stockholm University, Faculty of Science, Department of Materials and Environmental Chemistry (MMK), Environmental Chemistry.
2013 (English)In: Mass Spectrometry, ISSN 2186-5116, Vol. 2, no Special Issue, S0018- p.Article in journal (Refereed) Published
Abstract [en]

Comprehensive two-dimensional gas chromatography/time-of-flight mass spectrometry (GC×GC TOFMS) and gaschromatography/high-resolution time-of-flight mass spectrometry (GC-HRT) were used to detect and identify halogenatednatural products (HNPs) in tissue homogenate, in this case brominated analytes present in a marine snail. Two classes of brominatedanthropogenic compounds, polybrominated diphenyl ethers (PBDEs) and brominated dibenzofurans, were analyzedfor comparison. Following conventional preparation, the sample was analyzed using GC×GC-TOF-MS. Isotope ratio scriptswere used to compile a list of putatively brominated analytes from amongst the thousands of features resolved in the twodimensionalchromatogram. The structured nature of the chromatogram was exploited to propose identifications for severalclasses of brominated compounds, and include additional candidates that fell marginally outside the script tolerances. Thesample was subsequently analyzed by GC-HRT. The high-resolution mass spectral data confirmed many formula assignments,facilitated confident assignment of an alternate formula when an original proposal did not hold, and enabled unknown identification.Identified HNPs include hydroxylated and methoxylated PBDE analogs, polybrominated dibenzo-p-dioxins (PBDDs)and hydroxyl-PBDDs, permitting the environmental occurrence and fate of such compounds to be studied.

Place, publisher, year, edition, pages
2013. Vol. 2, no Special Issue, S0018- p.
Keyword [en]
GC×GC, multi-reflectron TOF, halogenated natural products, dioxins, screening, emerging pollutants
National Category
Analytical Chemistry
URN: urn:nbn:se:su:diva-94954DOI: 10.5702/massspectrometry.S0018OAI: diva2:657176
19th International Mass Spectrometry Conference, September 15-21, 2012, Kyoto, Japan
Available from: 2013-10-18 Created: 2013-10-18 Last updated: 2013-10-24Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Löfstrand, KarinAsplund, Lillemor
By organisation
Department of Applied Environmental Science (ITM)Environmental Chemistry
Analytical Chemistry

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 468 hits
ReferencesLink to record
Permanent link

Direct link