Transient effects of 2,4-dichlorophenoxyacetic acid (2,4-D) exposure on some metabolic and free radical processes in goldfish white muscle
2013 (English)In: Food and Chemical Toxicology, ISSN 0278-6915, E-ISSN 1873-6351, Vol. 59, 356-361 p.Article in journal (Refereed) Published
This study aims to assess effects of 96 h goldfish exposure to 1, 10 and 100 mg/L of the herbicide, 2,4-dichlorophenoxyacetic acid (2,4-D), on metabolic indices and free radical process markers in white muscle of a commercial fish, the goldfish Carassius auratus L. Most oxidative stress markers and antioxidant enzymes were not affected at 2,4-D fish treatment. 2,4-D fish exposure induced the elevated levels of total (by 46% and 40%) and reduced (by 77% and 73%) glutathione in muscles of goldfish of 10 mg/L 2,4-D and recovery (after 100 mg/L of 2,4-D exposure) groups, respectively. However, in muscles of 100 mg/L 2,4-D exposed goldfish these parameters were depleted (by 47% and 64%). None of investigated parameters of protein and carbohydrate metabolisms changed in white muscles of 2,4-D exposed fish, with exception of lactate dehydrogenase activity, which was slightly (by 11-15%) elevated in muscles of goldfish exposed to 10-100 mg/L of 2,4-D, but also recovered. Thus, the short term exposure of goldfish to the selected concentrations of 2,4-D does not substantially affect their white muscle, suggesting the absence of any effect under the environmentally relevant concentrations. .
Place, publisher, year, edition, pages
2013. Vol. 59, 356-361 p.
2, 4-Dichlorophenoxyacetic acid (2, 4-D), Goldfish, White muscle, Oxidative stress, Lactate, Transaminases (aminotransferases)
Food Science Pharmacology and Toxicology
IdentifiersURN: urn:nbn:se:su:diva-95087DOI: 10.1016/j.fct.2013.06.023ISI: 000324280000045OAI: oai:DiVA.org:su-95087DiVA: diva2:658581
Ministry of Education and Science of Ukraine 0106U002245 2013-10-222013-10-212013-10-22Bibliographically approved