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Complex aberrations in lymphocytes exposed to mixed beams of Am-241 alpha particles and X-rays
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. (Andrzej Wojcik)
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. (Andrzej Wojcik)
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute. (Andrzej Wojcik)
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
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2013 (English)In: Mutation research. Genetic toxicology and environmental mutagenesis, ISSN 1383-5718, E-ISSN 1879-3592, Vol. 756, no 1-2, 95-100 p.Article in journal (Refereed) Published
Abstract [en]

Modern radiotherapy treatment modalities are associated with undesired out-of-field exposure to complex mixed beams of high and low energy transfer (LET) radiation that can give rise to secondary cancers. The biological effectiveness of mixed beams is not known. The aim of the investigation was the analysis of chromosomal damage in human peripheral blood lymphocytes (PBL) exposed to a mixed beam of X-rays and alpha particles. Using a dedicated exposure facility PBL were exposed to increasing doses of alpha particles (from Am-241), X-rays and a mixture of both. Chromosomal aberrations were analysed in chromosomes 2,8 and 14 using fluorescence in situ hybridisation. The found and expected frequencies of simple and complex aberrations were compared. Simple aberrations showed linear dose-response relationships with doses. A higher than expected frequency of simple aberrations was only Observed after the highest mixed beam dose. A linear-quadratic dose response curve for complex aberrations was observed after mixed-beam exposure. Higher than expected frequencies of complex aberrations were observed for the two highest doses. Both the linear-quadratic dose-response relationship and the calculation of expected frequencies show that exposure of PBL to mixed beams of high and low LET radiation leads to a higher than expected frequency of complex-type aberrations. Because chromosomal changes are associated with cancer induction this result may imply that the cancer risk of exposure to mixed beams in radiation oncology may be higher than expected based on the additive action of the individual dose components.

Place, publisher, year, edition, pages
2013. Vol. 756, no 1-2, 95-100 p.
Keyword [en]
Mixed beams, Radiotherapy, High LET, Low LET, Aberrations
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy) Genetics
Identifiers
URN: urn:nbn:se:su:diva-96119DOI: 10.1016/j.mrgentox.2013.05.001ISI: 000325600300013OAI: oai:DiVA.org:su-96119DiVA: diva2:663855
Note

AuthorCount:6;

Funding agencies:

Swedish Radiation Protection Authority SSM

Available from: 2013-11-13 Created: 2013-11-11 Last updated: 2017-12-06Bibliographically approved

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Staaf, ElinaDeperas-Kaminska, MartaBrehwens, KarlHaghdoost, SiamakWojcik, Andrzej
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Department of Molecular Biosciences, The Wenner-Gren Institute
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Mutation research. Genetic toxicology and environmental mutagenesis
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)Genetics

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