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Sleep Duration and Survival Percentiles Across Categories of Physical Activity
Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol.
Stockholm University, Faculty of Social Sciences, Stress Research Institute. (Biologisk psykologi och behandlingsforskning)
Karolinska Inst, Inst Environm Med, Unit Nutr Epidemiol.
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2014 (English)In: American Journal of Epidemiology, ISSN 0002-9262, E-ISSN 1476-6256, Vol. 179, no 4, 484-491 p.Article in journal (Refereed) Published
Abstract [en]

The association between long sleep duration and death is not fully understood. Long sleep is associated with low physical activity, which is a strong predictor of death. Our aim was to investigate the association between sleep duration and death across categories of total physical activity in a large prospective cohort of Swedish men and women. We followed a population-based cohort of 70,973 participants (37,846 men and 33,127 women), aged 45-83 years, from January 1998 to December 2012. Sleep duration and physical activity levels were assessed through a questionnaire. We evaluated the association of interest in terms of mortality rates by estimating hazard ratios with Cox regression and in terms of survival by evaluating 15th survival percentile differences with Laplace regression. During 15 years of follow-up, we recorded 14,575 deaths (8,436 men and 6,139 women). We observed a significant interaction between sleep duration and physical activity in predicting death (P < 0.001). Long sleep duration (>8 hours) was associated with increased mortality risk (hazard ratio = 1.24; 95% confidence interval: 1.11, 1.39) and shorter survival (15th percentile difference = -20 months; 95% confidence interval: -30, -11) among only those with low physical activity. The association between long sleep duration and death might be partly explained by comorbidity with low physical activity.

Place, publisher, year, edition, pages
2014. Vol. 179, no 4, 484-491 p.
Keyword [sv]
Laplace regression, mortality, percentile, physical activity, prospective studies, sleep duration, survival
National Category
Medical and Health Sciences Environmental Health and Occupational Health
URN: urn:nbn:se:su:diva-96740DOI: 10.1093/aje/kwt280ISI: 000331264100011PubMedID: 24264294Local ID: P3057OAI: diva2:667281
Swedish Research Council

AuthorCount: 5;

Other Funders:

Karolinska Institutet's Strategic Program in Epidemiology;  Swedish Medical Society SLS-250271 

Available from: 2013-11-26 Created: 2013-11-26 Last updated: 2014-07-23Bibliographically approved

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Åkerstedt, Torbjörn
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