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Decreased medial temporal lobe activation in BDNF 66Met allele carriers during memory encoding
Stockholm University, Faculty of Social Sciences, Department of Psychology.
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2013 (English)In: Neuropsychologia, ISSN 0028-3932, E-ISSN 1873-3514, Vol. 51, no 12, 2462-2468 p.Article in journal (Refereed) Published
Abstract [en]

The Met allele of the Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has been associated with impaired activity-dependent secretion of BDNF protein and decreased memory performance. Results from imaging studies relating Val66Met to brain activation during memory processing have been inconsistent, with reports of both increased and decreased activation in the Medial Temporal Lobe (MTL) in Met carriers relative to Val homozygotes. Here, we extensively studied BDNF Val66Met in relation to brain activation and white matter integrity as well as memory performance in a large imaging (n=194) and behavioral (n=2229) sample, respectively. Functional magnetic resonance imaging (fMRI) was used to investigate MTL activation in healthy participants in the age of 55–75 years during a face-name episodic encoding and retrieval task. White matter integrity was measured using diffusion tensor imaging.

BDNF Met allele carriers had significantly decreased activation in the MTL during encoding processes, but not during retrieval processes. In contrast to previous proposals, the effect was not modulated by age and the polymorphism was not related to white matter integrity. Met carriers had lower memory performance than Val homozygotes, but differences were subtle and not significant. In conclusion, the BDNF Met allele has a negative influence on MTL functioning, preferentially during encoding processes, which might translate into impaired episodic memory function.

Place, publisher, year, edition, pages
Elsevier, 2013. Vol. 51, no 12, 2462-2468 p.
Keyword [en]
imaging, genetics, memory, Val66Met, parahippocampus
National Category
Psychology
Research subject
Psychology
Identifiers
URN: urn:nbn:se:su:diva-96751DOI: 10.1016/j.neuropsychologia.2012.11.028ISI: 000328526800014OAI: oai:DiVA.org:su-96751DiVA: diva2:667343
Note

This work was supported by the Swedish Science Council and a Wallenberg Scholar Grant from the Knut and Alice Wallenberg Foundation (to L.N.). The Betula project is supported by a grant from the Swedish Science Council (315-2004-6977 to L.G.N. and L.N.). E.E. was supported by a grant from the Swedish Science Council (grant no 1064), Torsten and Ragnar Söderberg's Foundation, Bertil Hållstens Foundation/Swedish Brain Foundation, and the Swedish Brain Power Initiative. We thank Alireza Salami and the staff at Betula and Umeå Center for Functional Brain Imaging.

Available from: 2013-11-26 Created: 2013-11-26 Last updated: 2017-12-06Bibliographically approved

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