Synergy effects of HbA(1c) and variants of APOE and BDNFVal(66)Met explains individual differences in memory performance
2013 (English)In: Neurobiology of Learning and Memory, ISSN 1074-7427, E-ISSN 1095-9564, Vol. 106, 274-282 p.Article in journal (Refereed) Published
We aimed at exploring if synergy effects of Brain-Derived Neurotrophic Factor (BDNF) Val66Met, Apolipoprotein E (APOE) and HbA1c (glycated haemoglobin) could explain individual differences in memory performance over 10 years in a population based sample of nondemented adults (N = 888, 35–85 years at baseline). Episodic memory was affected by such agents, wheras semantic memory was spared. Both age and HbA1c were associated with episodic memory decline. BDNF66Met carriers with higher HbA1c levels evidenced slope decline in episodic recall. We found support for joint effects ofBDNFVal66Met × APOE × HbA1c and BDNFVal66Met × APOE × age on rates of episodic memory change over ten years, after controlling for age, sex, education and cardiovascular diseases. We conclude that variants of genetic polymorphisms act in synergy with long-term blood glucose control in shaping patterns of cognitive aging.
Place, publisher, year, edition, pages
2013. Vol. 106, 274-282 p.
aging, episodic memory, BDNF, APOE, HbA1c, epistasis
Research subject Psychology
IdentifiersURN: urn:nbn:se:su:diva-96762DOI: 10.1016/j.nlm.2013.08.017ISI: 000328520800032OAI: oai:DiVA.org:su-96762DiVA: diva2:667381
The Betula Longitudinal Study was supported by the Bank of Sweden Tercentenary Foundation, Tercentenary Foundation (Grant 1988-0082:17), the Swedish Council for Planning and Coordination of Research (Grants D1988-0092, D1989-0115, D1990-0074, D1991-0258, D1992-0143, D1997-0756, D1997-1841, D1999-0739, and B1999-474), the Swedish Council for Research in the Humanities and Social Sciences (Grant F377/1988-2000), and the Swedish Council for Social Research (1998-1990: Grants 88-0082 and 311/1991-2000). Ninni Persson was funded by the Royal Swedish Academy of Sciences (Grant FOA11H-349), the American Scandinavian Foundation, and the Lars Hierta Memorial Foundation (Grant FO2011-0504). Åke Wahlin was funded by a grant from the Swedish Council for research in the Humanities and Social Sciences (Grant 421-2007-1616).2013-11-262013-11-262015-11-18Bibliographically approved