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Midlife and Late-Life Body Mass Index and Late-Life Dementia: Results from a Prospective Population-Based Cohort
Univ Eastern Finland, Dept Neurol, Kuopio, Finland.
Natl Inst Hlth & Welf, Dept Chron Dis Prevent, Helsinki, Finland.
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Jonkoping Univ, Sch Hlth Sci, Inst Gerontol, Jonkoping, Sweden.
Hosp Dist North Karelia, Joensuu, Finland.
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2014 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, Vol. 38, no 1, 201-209 p.Article in journal (Refereed) Published
Abstract [en]

Background: Obesity has been consistently associated with dementia. The role of certain risk factors of dementia may change during life, and the importance of having a life-course perspective has been acknowledged. Objective: The aim of this study was to investigate the association of midlife and late-life body mass index (BMI) with late-life dementia/ Alzheimer's disease (AD) and whether the association was independent of other obesity-related co-morbidities. Methods: The association between midlife BMI (mean age 50.2, SD 6.0) and late-life BMI (mean age 71.2, SD 4.0) and incident dementia later in life (mean age 75.7, SD 5.0) were investigated among 1,304 participants of the longitudinal population-based Cardiovascular risk factors, Aging and Dementia (CAIDE) study, conducted in Eastern Finland. The duration of follow-up was 26 years. The diagnosis of dementia was based on DSM-IV criteria and the probable and possible AD on the NINCDS-ADRDA criteria. Results: Higher midlife BMI was associated with higher risk of incident dementia (adjusted HR, 95% CI 1.07, 1.00-1.14). However, decrease in BMI from midlife to late-life was associated with higher risk of dementia (1.14, 1.03-1.25 for one-unit decrease) andAD(1.20, 1.09-1.33). High late-lifeBMIwas associated with lower risk ofAD(0.89, 0.81-0.98) but the association with dementia was less evident (0.94, 0.86-1.03). Conclusion: Higher midlife BMI is related to higher risk of dementia and AD, independently of obesity-related risk factors and co-morbidities. Steeper decrease of BMI and low late-life BMI are associated with higher risk of dementia and AD. These findings highlight the importance of life-course perspective when assessing the association between BMI and cognition.

Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2014. Vol. 38, no 1, 201-209 p.
Keyword [en]
Alzheimer's disease, body mass index, dementia, obesity
National Category
URN: urn:nbn:se:su:diva-97022DOI: 10.3233/JAD-130698ISI: 000326380300018OAI: diva2:675456


Funding agencies:

University of Eastern Finland;  Swedish Society for Medical Research and MR;  National Graduate School of Clinical Investigation 

Available from: 2013-12-03 Created: 2013-12-02 Last updated: 2013-12-03Bibliographically approved

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Aging Research Center (ARC), (together with KI)
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