Midlife and Late-Life Body Mass Index and Late-Life Dementia: Results from a Prospective Population-Based Cohort
2014 (English)In: Journal of Alzheimer's Disease, ISSN 1387-2877, Vol. 38, no 1, 201-209 p.Article in journal (Refereed) Published
Background: Obesity has been consistently associated with dementia. The role of certain risk factors of dementia may change during life, and the importance of having a life-course perspective has been acknowledged. Objective: The aim of this study was to investigate the association of midlife and late-life body mass index (BMI) with late-life dementia/ Alzheimer's disease (AD) and whether the association was independent of other obesity-related co-morbidities. Methods: The association between midlife BMI (mean age 50.2, SD 6.0) and late-life BMI (mean age 71.2, SD 4.0) and incident dementia later in life (mean age 75.7, SD 5.0) were investigated among 1,304 participants of the longitudinal population-based Cardiovascular risk factors, Aging and Dementia (CAIDE) study, conducted in Eastern Finland. The duration of follow-up was 26 years. The diagnosis of dementia was based on DSM-IV criteria and the probable and possible AD on the NINCDS-ADRDA criteria. Results: Higher midlife BMI was associated with higher risk of incident dementia (adjusted HR, 95% CI 1.07, 1.00-1.14). However, decrease in BMI from midlife to late-life was associated with higher risk of dementia (1.14, 1.03-1.25 for one-unit decrease) andAD(1.20, 1.09-1.33). High late-lifeBMIwas associated with lower risk ofAD(0.89, 0.81-0.98) but the association with dementia was less evident (0.94, 0.86-1.03). Conclusion: Higher midlife BMI is related to higher risk of dementia and AD, independently of obesity-related risk factors and co-morbidities. Steeper decrease of BMI and low late-life BMI are associated with higher risk of dementia and AD. These findings highlight the importance of life-course perspective when assessing the association between BMI and cognition.
Place, publisher, year, edition, pages
Institute of Physics Publishing (IOPP), 2014. Vol. 38, no 1, 201-209 p.
Alzheimer's disease, body mass index, dementia, obesity
IdentifiersURN: urn:nbn:se:su:diva-97022DOI: 10.3233/JAD-130698ISI: 000326380300018OAI: oai:DiVA.org:su-97022DiVA: diva2:675456
University of Eastern Finland; Swedish Society for Medical Research and MR; National Graduate School of Clinical Investigation 2013-12-032013-12-022013-12-03Bibliographically approved