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Association between EEG abnormalities and CSF biomarkers in a memory clinic cohort
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
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2013 (English)In: Dementia and Geriatric Cognitive Disorders, ISSN 1420-8008, E-ISSN 1421-9824, Vol. 36, no 5-6, 319-328 p.Article in journal (Refereed) Published
Abstract [en]

Background: The aim of the study was to describe distinct electroencephalogram (EEG) phenotypes defined after routine visual EEG analysis in a large memory clinic cohort and to investigate their relationship to cerebrospinal fluid (CSF) biomarkers. Methods: Patients with Alzheimer's disease (n = 131), mild cognitive impairment (n = 285), subjective cognitive impairment (n = 310), and mixed dementia (n = 29) were assessed clinically with neuroimaging, EEG and CSF investigations. EEG phenotypes were based on frequency of background activity (BA) and presence and degree of episodic abnormalities (EA). Results: BA and EA differed significantly (p < 0.001) between diagnostic groups. A lower CSF amyloid β42/phospho-tau ratio and higher total tau were associated with slower BA (p < 0.01) and a higher degree of EA (p < 0.04). Conclusions: Slowing of BA in combination with EA seems to be related to biological markers of neurodegeneration

Place, publisher, year, edition, pages
S. Karger, 2013. Vol. 36, no 5-6, 319-328 p.
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Geriatrics Neurosciences Psychiatry Gerontology, specializing in Medical and Health Sciences
Identifiers
URN: urn:nbn:se:su:diva-97762DOI: 10.1159/000351677ISI: 000328328800006OAI: oai:DiVA.org:su-97762DiVA: diva2:680036
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AuthorCount:6

Available from: 2013-12-17 Created: 2013-12-17 Last updated: 2017-12-06Bibliographically approved

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Aging Research Center (ARC), (together with KI)
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Dementia and Geriatric Cognitive Disorders
GeriatricsNeurosciencesPsychiatryGerontology, specializing in Medical and Health Sciences

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