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Therapeutic potential of cell-penetrating peptides
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-7522-8964
Stockholm University, Faculty of Science, Department of Neurochemistry.ORCID iD: 0000-0001-6107-0844
2013 (English)In: Therapeutic delivery, ISSN 2041-5990, E-ISSN 2041-6008, Vol. 4, no 5, 573-591 p.Article in journal (Refereed) Published
Abstract [en]

The ability of cell-penetrating peptides to cross plasma membranes has been used for various applications, including the delivery of bioactive molecules to inhibit disease-producing cellular mechanisms. Selective drug delivery into target cells improves drug distribution and decreases dosing and toxicity. In this review, the authors outline the main challenges in the field, namely clarification of mechanisms of entry into cells, as well as current and future perspectives regarding cell-penetrating peptides application for human therapeutics. Here, the authors discuss some of the factors that influence efficacy of delivery and review the current status of preclinical studies and clinical trials involving the use of cell-penetrating peptide-mediated delivery of therapeutics.

Place, publisher, year, edition, pages
2013. Vol. 4, no 5, 573-591 p.
Keyword [en]
CPP, Cell-penetrating peptide
National Category
Biological Sciences Chemical Sciences
Research subject
Neurochemistry with Molecular Neurobiology
URN: urn:nbn:se:su:diva-98638DOI: 10.4155/tde.13.22PubMedID: 23647276OAI: diva2:684728
Available from: 2014-01-08 Created: 2014-01-08 Last updated: 2015-04-21Bibliographically approved

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Vasconcelos, LuísLangel, Ülo
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