Enzyme- and Ruthenium-Catalyzed Dynamic Kinetic Resolution of Functionalized Cyclic Allylic Alcohols
2013 (English)In: Journal of Organic Chemistry, ISSN 0022-3263, E-ISSN 1520-6904, Vol. 78, no 23, 12114-12120 p.Article in journal (Refereed) Published
Enantioselective synthesis of functionalized cyclic allylic alcohols via dynamic kinetic resolution has been developed. Cyclopentadienylruthenium catalysts were used for the racemization, and lipase PS-IM or CALB was employed for the resolution. By optimization of the reaction conditions the formation of the enone byproduct was minimized, making it possible to prepare a range of optically active functionalized allylic alcohols in good yields and high ee's.
Place, publisher, year, edition, pages
2013. Vol. 78, no 23, 12114-12120 p.
IdentifiersURN: urn:nbn:se:su:diva-98273DOI: 10.1021/jo402086zISI: 000328231600050OAI: oai:DiVA.org:su-98273DiVA: diva2:685665
FunderSwedish Research CouncilKnut and Alice Wallenberg Foundation