Change search
ReferencesLink to record
Permanent link

Direct link
Effects of mPGES-1 deletion on eicosanoid and fatty acid profiles in mice
Stockholm University, Faculty of Science, Department of Analytical Chemistry.
Show others and affiliations
2013 (English)In: Prostaglandins & other lipid mediators, ISSN 1098-8823, Vol. 107, 18-25 p.Article in journal (Refereed) Published
Abstract [en]

mPGES-1 is considered an alternative target for anti-inflammatory treatment with improved selectivity and safety compared to NSAIDs. mPGES-1 depletion not only suppresses inflammation via absence of inducible PGE2 but might also cause an activation of anti-inflammatory pathways. We studied effects of mPGES-1 deletion on the eicosanoid and fatty acid (FA) profiles in mice. In LPS-induced peritoneal macrophages from mPGES-1 knock-out (mPGES-1−/−, KO) mice PGE2 production was markedly attenuated, whereas levels of PGD2 metabolites (15-deoxy-Δ12,14 PGJ2 and 15-deoxy-Δ12,14 PGD2) were increased compared to wild type mice. The levels of oxidized fatty acid 13-HODE were also significantly up-regulated in KO macrophages. Significant differences in the total lipid FA composition (decrease in monounsaturated FA and increase in eicosadienoic acid) were detected in spleen of KO and WT mice. These effects of mPGES-1 deletion on eicosanoid and fatty acid metabolism have important implications for future mPGES-1 inhibitors and deserve further investigation

Place, publisher, year, edition, pages
2013. Vol. 107, 18-25 p.
Keyword [en]
mPGES-1, Prostaglandins E2, Eicosanoids, Fatty acids, Knock-out mice, Inflammation
National Category
Analytical Chemistry
URN: urn:nbn:se:su:diva-98960DOI: 10.1016/j.prostaglandins.2013.07.004ISI: 000328713600004OAI: diva2:685975
4th European Workshop on Lipid Mediators
Swedish Research Council

Funding agencies:

Swedish Research Council; Swedish Rheumatism Association; Karolinska Institutet Foundation; King Gustaf V 80-Year Fund; Marianne and Marcus Wallenberg Foundation, VINNOVA; Apotekare Hedbergs foundation; Sigurd and Elsa Goljes minnesfond 

Available from: 2014-01-10 Created: 2014-01-10 Last updated: 2014-01-20Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Olsson, Petter
By organisation
Department of Analytical Chemistry
In the same journal
Prostaglandins & other lipid mediators
Analytical Chemistry

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 29 hits
ReferencesLink to record
Permanent link

Direct link