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Dopaminergic gene polymorphisms affect long-term forgetting in old age: further support for the magnification hypothesis
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
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2013 (English)In: Journal of cognitive neuroscience, ISSN 0898-929X, E-ISSN 1530-8898, Vol. 25, no 4, 571-579 p.Article in journal (Refereed) Published
Abstract [en]

Emerging evidence from animal studies suggests that suboptimal dopamine (DA) modulation may be associated with increased forgetting of episodic information. Extending these observations, we investigated the influence of DA-relevant genes on forgetting in samples of younger (n = 433, 20–31 years) and older (n = 690, 59–71 years) adults. The effects of single nucleotide polymorphisms of the DA D2 (DRD2) and D3 (DRD3) receptor genes as well as the DA transporter gene (DAT1; SLC6A3) were examined. Over the course of one week, older adults carrying two or three genotypes associated with higher DA signaling (i.e., higher availability of DA and DA receptors) forgot less pictorial information than older individuals carrying only one or no beneficial genotype. No such genetic effects were found in younger adults. The results are consistent with the view that genetic effects on cognition are magnified in old age. To the best of our knowledge, this is the first report to relate genotypes associated with suboptimal DA modulation to more long-term forgetting in humans. Independent replication studies in other populations are needed to confirm the observed association.

Place, publisher, year, edition, pages
2013. Vol. 25, no 4, 571-579 p.
National Category
Gerontology, specializing in Medical and Health Sciences Psychology
Identifiers
URN: urn:nbn:se:su:diva-99759OAI: oai:DiVA.org:su-99759DiVA: diva2:688544
Available from: 2014-01-17 Created: 2014-01-17 Last updated: 2017-12-06Bibliographically approved

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