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Iridium Catalysts with Chiral Bicyclic Pyridine-Phosphane Ligands for the Asymmetric Hydrogenation of Olefins
Uppsala University, Sweden.
Stockholm University, Faculty of Science, Department of Organic Chemistry.
University of KwaZulu-Natal, South Africa.
Stockholm University, Faculty of Science, Department of Organic Chemistry. University of KwaZulu-Natal, South Africa.
2014 (English)In: European Journal of Organic Chemistry, ISSN 1434-193X, E-ISSN 1099-0690, Vol. 2014, no 1, 140-146 p.Article in journal (Refereed) Published
Abstract [en]

New bicyclic pyridine-phosphane ligands were prepared, and their iridium complexes were evaluated in asymmetric hydrogenation of trisubstituted olefins with non-coordinating and weakly coordinating substituents. The iridium catalysts showed high reactivity and enantioselectivity for both types of olefins.

Place, publisher, year, edition, pages
2014. Vol. 2014, no 1, 140-146 p.
Keyword [en]
Iridium, N, P ligands, Homogeneous catalysis, Hydrogenation, Asymmetric catalysis
National Category
Organic Chemistry
Research subject
Organic Chemistry
Identifiers
URN: urn:nbn:se:su:diva-99864DOI: 10.1002/ejoc.201301141ISI: 000328631700016OAI: oai:DiVA.org:su-99864DiVA: diva2:690651
Funder
Swedish Research Council
Note

AuthorCount:4;

Available from: 2014-01-24 Created: 2014-01-20 Last updated: 2017-12-06Bibliographically approved
In thesis
1. Hydrogenation, Transfer Hydrogenation and Hydrogen Transfer Reactions Catalyzed by Iridium Complexes
Open this publication in new window or tab >>Hydrogenation, Transfer Hydrogenation and Hydrogen Transfer Reactions Catalyzed by Iridium Complexes
2015 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The work described in this thesis is focused on the development of new bidentate iridium complexes and their applications in the asymmetric reduction of olefins, ketones and imines. Three new types of iridium complexes were synthesized, which included pyridine derived chiral N,P-iridium complexes, achiral NHC complexes and chiral NHC-phosphine complexes. A study of their catalytic applications demonstrated a high efficiency of the N,P-iridium complexes for asymmetric hydrogenation of olefins, with good enantioselectivity. The carbene complexes were found to be very efficient hydrogen transfer mediators capable of abstracting hydrogen from alcohols and subsequently transfer it to other unsaturated bonds. This hydrogen transferring property of the carbene complexes was used in the development of C–C and C–N bond formation reactions via the hydrogen borrowing process. The complexes displayed high catalytic reactivity using 0.5–1.0 mol% of the catalyst and mild reaction conditions. Finally chiral carbene complexes were found to be activated by hydrogen gas. Their corresponding iridium hydride species were able to reduce ketones and imines with high efficiency and enantioselectivity without any additives, base or acid.

Place, publisher, year, edition, pages
Stockholm: Department of Organic Chemistry, Stockholm University, 2015. 69 p.
Keyword
Iridium catalyst, carbene, N, P - ligand, asymmetric hydrogenation, transfer hydrogenation, hydrogen transfer reaction, alkylation, olefin, ketone, amide
National Category
Organic Chemistry
Research subject
Organic Chemistry
Identifiers
urn:nbn:se:su:diva-119701 (URN)978-91-7649-255-0 (ISBN)
Public defence
2015-09-30, Magnélisalen, Kemiska övningslaboratoriet, Svante Arrhenius väg 16 B, Stockholm, 10:15 (English)
Opponent
Supervisors
Note

At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 5: Submitted. Paper 6: Manuscript.

 

Available from: 2015-09-08 Created: 2015-08-21 Last updated: 2015-09-08Bibliographically approved

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