Change search
ReferencesLink to record
Permanent link

Direct link
Incidence of stroke in people with Alzheimer disease: a national register-based approach
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Institute of Clinical Medicine-Neurology, University of Eastern Finland, Kuopio, Finland.
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
Show others and affiliations
2013 (English)In: Neurology, ISSN 0028-3878, E-ISSN 1526-632X, Vol. 80, no 4, 353-358 p.Article in journal (Refereed) Published
Abstract [en]

Objective: Stroke increases the risk of dementias, including Alzheimer disease (AD), but it is unknown whether persons with AD have a higher risk of strokes. We investigated whether noninstitutionalized persons with AD were more likely to experience incident stroke than persons without AD and whether there are differences in the incidence of ischemic or hemorrhagic strokes.

Methods: We performed a register-based matched cohort study including all community-dwelling persons with verified clinical diagnosis of AD, residing in Finland on December 31, 2005, and a single age-, sex-, and region of residence–matched comparison person without AD for each individual with AD (n = 56,186, mean age 79.6 [SD 6.9] years). Persons with previous strokes and their matched participants were excluded, leaving 50,808 individuals with 2,947 incident strokes occurring between January 1, 2006, and December 31, 2009. Diagnosis of AD was based on prescription reimbursement register and diagnosis of stroke on hospital discharge register of Finland.

Results: AD dementia was not associated with risk of all strokes or ischemic strokes, but the risk of hemorrhagic strokes was higher among persons with AD (adjusted hazard ratio [95% confidence interval] 1.34 [1.12–1.61]). When the associations were analyzed according to age groups, AD was associated with higher risk of all strokes, regardless of etiology, in the 2 youngest age groups, but not in the older groups. Similar associations were observed when the results were categorized according to age at diagnosis.

Conclusions: Our findings suggest that persons with AD dementia, especially younger patients, have higher risk of hemorrhagic strokes.

Place, publisher, year, edition, pages
New York: Lippincott Williams & Wilkins, 2013. Vol. 80, no 4, 353-358 p.
National Category
Gerontology, specializing in Medical and Health Sciences
URN: urn:nbn:se:su:diva-100073DOI: 10.1212/WNL.0b013e31827f08c5OAI: diva2:691071
Available from: 2014-01-27 Created: 2014-01-27 Last updated: 2014-01-28Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text
By organisation
Aging Research Center (ARC), (together with KI)
In the same journal
Gerontology, specializing in Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 15 hits
ReferencesLink to record
Permanent link

Direct link