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A glycosylation-dependent CD45RB epitope defines previously unacknowledged CD27(-)IgM(high) B cell subpopulations enriched in young children and after hematopoietic stem cell transplantation
Stockholm University, Faculty of Science, The Wenner-Gren Institute, Immunology.
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2013 (English)In: Clinical Immunology, ISSN 1521-6616, E-ISSN 1521-7035, Vol. 149, no 3, 421-431 p.Article in journal (Refereed) Published
Abstract [en]

The immune system is dysfunctional for years after hematopoietic stem cell transplantation (HSCT). A potential cause is an intrinsic B cell deficiency. In a cohort of pediatric HSCT patients few CD27(+) B cells formed after transplantation with the number of CD27(+)IgM(high) cells more affected than class-switched ones. A previously unacknowledged population of CD27(-)IgM(high) cells made up the majority of B cells and this population was also enlarged in healthy children compared to adults. Only a minority of these CD27(-)IgM(high) B cells expressed markers typical for transitional B cells, and the non-transitional CD27(-)IgM(high) cells could be further divided into subpopulations based on their ability to extrude the dye Rhodamine 123 and their expression of CD45RB(MEM55), a glycosylation-dependent epitope. Thus, we define several novel human CD27(-)IgM(high) B cell subpopulations in blood, all of which are present in higher frequencies and numbers in young children and after HSCT than in adults.

Place, publisher, year, edition, pages
2013. Vol. 149, no 3, 421-431 p.
Keyword [en]
Hematopoietic stem cell transplantation, B cell, Lymphocyte development, Immunological ontogeny
National Category
Immunology
Identifiers
URN: urn:nbn:se:su:diva-100114DOI: 10.1016/j.clim.2013.08.011ISI: 000328874800007OAI: oai:DiVA.org:su-100114DiVA: diva2:691563
Note

AuthorCount:9;

Available from: 2014-01-28 Created: 2014-01-27 Last updated: 2017-12-06Bibliographically approved

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