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Mutations in the D-channel of cytochrome c oxidase causes leakage of the proton pump
Stockholm University, Faculty of Science, Department of Organic Chemistry.
Stockholm University, Faculty of Science, Department of Organic Chemistry.
2014 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 588, no 4, 545-548 p.Article in journal (Refereed) Published
Abstract [en]

It has experimentally been found that certain mutations close to the entry point of the proton transfer channel in cytochrome c oxidase stop proton translocation but not the oxygen reduction chemistry. This effect is termed uncoupling. Since the mutations are 20 angstrom away from the catalytic center, this is very surprising. A new explanation for this phenomenon is suggested here, involving a local effect at the entry point of the proton channel, rather than the long range effects suggested earlier. (C) 2013 Federation of European Biochemical Societies.

Place, publisher, year, edition, pages
Elsevier, 2014. Vol. 588, no 4, 545-548 p.
Keyword [en]
Cytochrome oxidase, Proton pumping, Computational modeling
National Category
Biochemistry and Molecular Biology Cell Biology
Identifiers
URN: urn:nbn:se:su:diva-101736DOI: 10.1016/j.febslet.2013.12.020ISI: 000331115700004OAI: oai:DiVA.org:su-101736DiVA: diva2:705688
Note

AuthorCount:2;

Available from: 2014-03-17 Created: 2014-03-14 Last updated: 2017-12-05Bibliographically approved

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Siegbahn, Per E. M.Blomberg, Margareta R. A.
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