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Cardiac regeneration in non-mammalian vertebrates
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
2014 (English)In: Experimental Cell Research, ISSN 0014-4827, E-ISSN 1090-2422, Vol. 321, no 1, 58-63 p.Article, review/survey (Refereed) Published
Abstract [en]

The heart is a robust organ, capable of pumping nutrients and transferring oxygen throughout the body via a network of capillaries, veins and arteries, for the entirety of a human's life. However, the fragility of mammalian hearts is also evident when it becomes damaged and parts of the organ fail to function. This is due to the fact that rather than replenishing the damaged areas with functional cellular mass, fibrotic scar tissue is the preferred replacement, resulting in an organ with functional deficiencies. Due to the mammalian hearts incapability to regenerate following damage and the ever-increasing number of people worldwide suffering from heart disease, tireless efforts are being made to discover ways of inducing a regenerative response in this most important organ. One such avenue of investigation involves studying our distantly related non-mammalian vertebrate cousins, which over the last decade has proved to us that cardiac regeneration is possible. This review will highlight these organisms and provide insights into some of the seminal discoveries made in the heart regeneration field using these amazing chordates.

Place, publisher, year, edition, pages
2014. Vol. 321, no 1, 58-63 p.
Keyword [en]
Heart, microRNA, Regeneration, Teleost, Urodele
National Category
Cancer and Oncology Cell Biology
Identifiers
URN: urn:nbn:se:su:diva-101743DOI: 10.1016/j.yexcr.2013.08.001ISI: 000331157200009OAI: oai:DiVA.org:su-101743DiVA: diva2:705727
Funder
Carl Tryggers foundation
Note

AuthorCount:2;

Other funding agencies:

Ake Wiberg Stiftelse;  Magn Bergvall Stiftelse 

Available from: 2014-03-17 Created: 2014-03-14 Last updated: 2017-12-05Bibliographically approved

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