Several phylogenetic studies in the Arctotideae-Gorteriinae (Asteraceae) have found support for aGazania-Gorteria-Hirpicium clade. The results have also indicated Hirpicium to be a paraphyleticgenus whereas Gorteria and Gazania have both been found to be monophyletic. Previousinvestigations at the genus level on this group have focused only on relationships in Gazania andGorteria, respectively, with only a few Hirpicium species included. In the present study we includemore taxa than in any previous investigation, including all species of Hirpicium, all species ofGorteria and virtually all taxa of Gazania. The resulting phylogenetical hypothesis, based on DNAdata from non-coding (rps16, trnL-F, and psbA-trnH) as well as coding (ndhF) regions from theplastid genome together with DNA data from the ribosomal regions (ETS and ITS) from the nucleargenome, suggests three major clades. No support for any relationships between these major cladescould be found but there is strong support for a monophyletic Gazania. The genus Hirpicium, aspresently circumscribed, is paraphyletic with one group of species nested within Gorteria while allremaining species of Hirpicium form a monophyletic group with two clades, morphologically welldefined,and with high molecular support. As the name Hirpicium is synonym of Gorteria, newnames for the remaining Hirpicium species must be proposed. For one of the Hirpicium clades wesuggest a resurrection of the genus name Berkheyopsis O.Hoffm., and for the species belonging tothe other clade a new generic name, Roessleria Stångb. & Anderb., is proposed. The necessaryrecombinations, 12 in total, are made, as well as five lectotypifications and one neotypification. Akey to the genera in their new circumscription is presented.