Tightly regulated migratory subversion of immune cells promotes the dissemination of Toxoplasma gondii
2014 (English)In: International Journal of Parasitology, ISSN 0020-7519, E-ISSN 1879-0135, Vol. 44, no 2, 85-90 p.Article, review/survey (Refereed) Published
While the spread of Toxoplasma gondii within the infected human or animal host is associated with pathology, the pathways of dissemination have remained enigmatic. From the time point of entry into the gut, to the quiescent chronic infection in the central nervous system, Toxoplasma is detected and surveyed by immune cells that populate the tissues, for example dendritic cells. Paradoxically, this protective migratory function of leukocytes appears to be targeted by Toxoplasma to mediate its dissemination in the organism. Recent findings show that tightly regulated events take place shortly after host cell invasion that promote the migratory activation of infected dendritic cells. Here, we review the emerging knowledge on how this obligate intracellular protozoan orchestrates the subversion of leukocytes to achieve systemic dissemination and reach peripheral organs where pathology manifests.
Place, publisher, year, edition, pages
2014. Vol. 44, no 2, 85-90 p.
Protozoa, Intracellular pathogen, Chemotaxis, Cell motility, Migration, Dendritic cell, Immune privileged organ, Host pathogen
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:su:diva-102083DOI: 10.1016/j.ijpara.2013.09.006ISI: 000331486900002OAI: oai:DiVA.org:su-102083DiVA: diva2:708414
FunderSwedish Research CouncilThe Wenner-Gren Foundation