NMR Investigation of Chloromethane Complexes of Cryptophane-A and Its Analogue with Butoxy Groups
2014 (English)In: Journal of Physical Chemistry B, ISSN 1520-6106, E-ISSN 1520-5207, Vol. 118, no 8, 2134-2146 p.Article in journal (Refereed) Published
Host guest complexes between cryptophane-A as host and dichloromethane and chloroform as guests are investigated using H-1 and C-13 NMR spectroscopy. Moreover, a related cryptophane, with the methoxy groups replaced by butoxy units (cryptophane-But), and its complexes with the same guests were also studied. Variable temperature spectra showed effects of chemical exchange between the free and bound guests, as well as of conformational exchange of the host. The guest exchange was studied quantitatively by exchange spectroscopy or line shape analysis. Extraction of kinetic and thermodynamic parameters led to the characterization of the affinity between guests and hosts. On the other hand, the host exchange was investigated by means of C-13 Carr-Purcell-Meiboom-Gill (CPMG) relaxation dispersion which aims at the determination of the transverse relaxation rate R-2, the inverse of the transverse relaxation time T-2, as a function of the repetition of the pi pulses in a CPMG train. The variation of the measured transverse relaxation rate with the repetition rate nu(CPMG) indicated conformational exchange occurring on the microsecond millisecond time scale. Structural information was obtained through measurements of cross-relaxation rates, both within the host and between the host and the guest protons. The NMR results were supported by DFT calculations.
Place, publisher, year, edition, pages
2014. Vol. 118, no 8, 2134-2146 p.
IdentifiersURN: urn:nbn:se:su:diva-102478DOI: 10.1021/jp4105272ISI: 000332188300019OAI: oai:DiVA.org:su-102478DiVA: diva2:710577
FunderSwedish Research Council, 613-2011-3311Knut and Alice Wallenberg Foundation