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Dopamine and glutamate receptor genes interactively influence episodic memory in old age
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI). Max Planck Institute for Human Development, Germany.
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2014 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 35, no 5, article id 1213.e3Article in journal (Refereed) Published
Abstract [en]

Both the dopaminergic and glutamatergic systems modulate episodic memory consolidation. Evidence from animal studies suggests that these two neurotransmitters may interact in influencing memory performance. Given that individual differences in episodic memory are heritable, we investigated whether variations of the dopamine D2 receptor gene (rs6277, C957T) and the N-methyl-D-aspartate 3A (NR3A) gene, coding for the N-methyl-D-aspartate 3A subunit of the glutamate N-methyl-D-aspartate receptor (rs10989591, Val362Met), interactively modulate episodic memory in large samples of younger (20-31 years; n = 670) and older (59-71 years; n = 832) adults. We found a reliable gene-gene interaction, which was observed in older adults only: older individuals carrying genotypes associated with greater D2 and N-methyl-D-aspartate receptor efficacy showed better episodic performance. These results are in line with findings showing magnification of genetic effects on memory in old age, presumably as a consequence of reduced brain resources. Our findings underscore the need for investigating interactive effects of multiple genes to understand individual difference in episodic memory.

Place, publisher, year, edition, pages
2014. Vol. 35, no 5, article id 1213.e3
Keyword [en]
Glutamate, Dopamine, Episodic memory, Aging, D2 receptors, NMDA receptors, Gene-gene interactions
National Category
Geriatrics Gerontology, specialising in Medical and Health Sciences Neurosciences
Identifiers
URN: urn:nbn:se:su:diva-102452DOI: 10.1016/j.neurobiolaging.2013.11.014ISI: 000332308300032OAI: oai:DiVA.org:su-102452DiVA, id: diva2:710839
Funder
Swedish Research Council
Note

AuthorCount:10;

Available from: 2014-04-08 Created: 2014-04-07 Last updated: 2018-05-02Bibliographically approved

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Neurobiology of Aging
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  • apa
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