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Dopamine and glutamate receptor genes interactively influence episodic memory in old age
Stockholm University, Faculty of Social Sciences, Aging Research Center (ARC), (together with KI).
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2014 (English)In: Neurobiology of Aging, ISSN 0197-4580, E-ISSN 1558-1497, Vol. 35, no 5, 1213.e3- p.Article in journal (Refereed) Published
Abstract [en]

Both the dopaminergic and glutamatergic systems modulate episodic memory consolidation. Evidence from animal studies suggests that these two neurotransmitters may interact in influencing memory performance. Given that individual differences in episodic memory are heritable, we investigated whether variations of the dopamine D2 receptor gene (rs6277, C957T) and the N-methyl-D-aspartate 3A (NR3A) gene, coding for the N-methyl-D-aspartate 3A subunit of the glutamate N-methyl-D-aspartate receptor (rs10989591, Val362Met), interactively modulate episodic memory in large samples of younger (20-31 years; n = 670) and older (59-71 years; n = 832) adults. We found a reliable gene-gene interaction, which was observed in older adults only: older individuals carrying genotypes associated with greater D2 and N-methyl-D-aspartate receptor efficacy showed better episodic performance. These results are in line with findings showing magnification of genetic effects on memory in old age, presumably as a consequence of reduced brain resources. Our findings underscore the need for investigating interactive effects of multiple genes to understand individual difference in episodic memory.

Place, publisher, year, edition, pages
2014. Vol. 35, no 5, 1213.e3- p.
Keyword [en]
Glutamate, Dopamine, Episodic memory, Aging, D2 receptors, NMDA receptors, Gene-gene interactions
National Category
Geriatrics Gerontology, specializing in Medical and Health Sciences Neurosciences
URN: urn:nbn:se:su:diva-102452DOI: 10.1016/j.neurobiolaging.2013.11.014ISI: 000332308300032OAI: diva2:710839
Swedish Research Council


Funding agencies:

Max Planck Society M.FE.Abild0006; German Federal Ministry of Education and Research 01G00501;  Swedish Brain Power;  Alexander von Humboldt Research Award  

Available from: 2014-04-08 Created: 2014-04-07 Last updated: 2014-04-08Bibliographically approved

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Neurobiology of Aging
GeriatricsGerontology, specializing in Medical and Health SciencesNeurosciences

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