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Supported Palladium Nanoparticles for Sustainable Cross-Coupling and Oxidation Reactions
Stockholm University, Faculty of Science, Department of Organic Chemistry.
2014 (English)Licentiate thesis, monograph (Other academic)
Abstract [en]

The work presented in this thesis aims to combine the rich chemistry ofpalladium and the benefits of heterogeneous catalysis with metal-organic frameworks(MOFs) in developing robust materials that are recyclable and adaptable to operationunder a continuous flow regime.

Two new catalysts were created based on palladium nanoparticles in themesoporous MOFs MIL-101 and MIL-88B. They were synthesized and rigorouslycharacterized. All the parameters that can influence the outcome of the desiredchemical transformations were investigated, leading to the development of veryefficient methodologies.

Pd@MIL-101-NH2 was employed in the Suzuki-Miyaura cross-couplingreaction and it displayed a remarkable efficiency in some of the mildest conditionsreported to date. Moreover, it displays a very good tolerance to highly functionalizedsubstrates, obtaining biaryl motifs that are of potential interest for the pharmaceuticalindustry. Also, a small library of 11 compounds could be synthesized in a singlecontinuous flow experiment proving that the catalyst is amenable to a packed-bedmicro-flow reactor.

An innovative double support was also used for encapsulating palladiumnanoparticles in a mixed MOF-silica matrix. The resulting material was denotedPd@MIL-88B-NH2@SiO2 and it was employed in a greener approach towards theaerobic oxidation of alcohols. The increased protection of the support allows thecatalyst to maintain a very good performance profile over 7 days of continuousoperation under high mechanical and chemical stress, with no sign of deactivation.

Place, publisher, year, edition, pages
Stockholm University, 2014. , 57 p.
National Category
Organic Chemistry
URN: urn:nbn:se:su:diva-102562OAI: diva2:711231
2014-04-29, 14:00 (English)
Available from: 2014-04-09 Created: 2014-04-09 Last updated: 2016-08-26Bibliographically approved

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Pascanu, Vlad
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