Contrasting effects of cold acclimation versus obesogenic diets onchemerin gene expression in brown and brite adipose tissues
(English)Manuscript (preprint) (Other academic)
Based on results from a signal sequence trap, we investigated chemerin gene expression in brown adipose tissue. Male NMRI mice were exposed to 30, 22 or 4 °C for 3 weeks, or were fed control (chow) diet, cafeteria diet or high-fat diet at thermoneutrality for the same time. In brown adipose tissue, cold acclimation strongly diminished chemerin gene expression, whereas obesogenic diets augmented expression. Qualitatively, changes in expression were paralleled in brite/beige adipose tissues (e.g. inguinal), whereas white adipose tissue (epididymal) did not react to these cues. Changes in tissue expression were not paralleled by alterations in plasma levels. The cellular regulation was not congruent with a sympathetic/adrenergic control of expression. The data are discussed in relation to suggested endocrine, paracrine and autocrine effects of this adipokine.
Natural Sciences Biochemistry and Molecular Biology
Research subject Physiology
IdentifiersURN: urn:nbn:se:su:diva-102923OAI: oai:DiVA.org:su-102923DiVA: diva2:714060