Regulation of body temperature and brown adipose tissue thermogenesis by bombesin receptor subtype-3
2014 (English)In: American Journal of Physiology. Endocrinology and Metabolism, ISSN 0193-1849, E-ISSN 1522-1555, Vol. 306, no 6, E681-E687 p.Article in journal (Refereed) Published
Bombesin receptor subtype-3 (BRS-3) regulates energy homeostasis, with Brs3 knockout (Brs3(-/y)) mice being hypometabolic, hypothermic, and hyperphagic and developing obesity. We now report that the reduced body temperature is more readily detected if body temperature is analyzed as a function of physical activity level and light/dark phase. Physical activity level correlated best with body temperature 4 min later. The Brs3(-/y) metabolic phenotype is not due to intrinsically impaired brown adipose tissue function or in the communication of sympathetic signals from the brain to brown adipose tissue, since Brs3(-/y) mice have intact thermogenic responses to stress, acute cold exposure, and beta 3-adrenergic activation, and Brs3(-/y) mice prefer a cooler environment. Treatment with the BRS-3 agonist MK-5046 increased brown adipose tissue temperature and body temperature in wild-type but not Brs3(-/y) mice. Intrahypothalamic infusion of MK5046 increased body temperature. These data indicate that the BRS-3 regulation of body temperature is via a central mechanism, upstream of sympathetic efferents. The reduced body temperature in Brs3(-/y) mice is due to altered regulation of energy homeostasis affecting higher center regulation of body temperature, rather than an intrinsic defect in brown adipose tissue.
Place, publisher, year, edition, pages
2014. Vol. 306, no 6, E681-E687 p.
bombesin receptor subtype-3, obesity, sympathetic nervous system, brown adipose tissue, thermoregulation, CL316243, MK-5046
Research subject Physiology
IdentifiersURN: urn:nbn:se:su:diva-102966DOI: 10.1152/ajpendo.00615.2013ISI: 000333332700010OAI: oai:DiVA.org:su-102966DiVA: diva2:714750