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Cell-Penetrating Peptides: Design, Synthesis, and Applications
Stockholm University, Faculty of Science, Department of Neurochemistry. University of Tartu, Estonia.ORCID iD: 0000-0001-6107-0844
2014 (English)In: ACS Nano, ISSN 1936-0851, Vol. 8, no 3, 1972-1994 p.Article, review/survey (Refereed) Published
Abstract [en]

The intrinsic property of cell-penetrating peptides (CPPs) to deliver therapeutic molecules (nucleic acids, drugs, imaging agents) to cells and tissues in a nontoxic manner has indicated that they may be potential components of future drugs and disease diagnostic agents. These versatile peptides are simple to synthesize, functionalize, and characterize yet are able to deliver covalently or noncovalently conjugated bioactive cargos (from small chemical drugs to large plasmid DNA) inside cells, primarily via endocytosis, in order to obtain high levels of gene expression, gene silencing, or tumor targeting. Typically, CPPs are often passive and nonselective yet must be functionalized or chemically modified to create effective delivery vectors that succeed in targeting specific cells or tissues. Furthermore, the design of clinically effective systemic delivery systems requires the same amount of attention to detail in both design of the delivered cargo and the cell-penetrating peptide used to deliver it.

Place, publisher, year, edition, pages
2014. Vol. 8, no 3, 1972-1994 p.
Keyword [en]
cell-penetrating peptides, delivery agents, uptake mechanism, nanoparticles, gene therapy, nucleic acids
National Category
Chemical Sciences
URN: urn:nbn:se:su:diva-103309DOI: 10.1021/nn4057269ISI: 000333539400016OAI: diva2:717578


Available from: 2014-05-15 Created: 2014-05-12 Last updated: 2015-04-21Bibliographically approved

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Langel, Ülo
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