Readily Available Ruthenium Complex for Efficient Dynamic Kinetic Resolution of Aromatic alpha-Hydroxy Ketones
2014 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 16, no 8, 2256-2259 p.Article in journal (Refereed) Published
A ruthenium complex formed from commercially available [Ru(p-cymene)Cl-2](2) and 1,4-bis(diphenylphosphino)butane catalyzes the racemization of aromatic alpha-hydroxy ketones very efficiently at room temperature. The racemization is fully compatible with a kinetic resolution catalyzed by a lipase from Pseudomonas stutzeri. This is the first example of dynamic kinetic resolution of alpha-hydroxy ketones at ambient temperature in which the metal and enzyme catalysts work in concert in one pot at room temperature to give quantitative yields of esters of alpha-hydroxy ketones with very high enantioselectivity.
Place, publisher, year, edition, pages
2014. Vol. 16, no 8, 2256-2259 p.
IdentifiersURN: urn:nbn:se:su:diva-104150DOI: 10.1021/ol500764qISI: 000334823600047OAI: oai:DiVA.org:su-104150DiVA: diva2:722636