Room Temperature, Metal-Free Arylation of Aliphatic Alcohols
2014 (English)In: ChemistryOpen, ISSN 2191-1363, Vol. 3, no 2, 54-57 p.Article in journal (Refereed) Published
Diaryliodonium salts are demonstrated as efficient arylating agents of aliphatic alcohols under metal-free conditions. The reaction proceeds at room temperature within 90min to give alkyl aryl ethers in good to excellent yields. Aryl groups with electron-withdrawing substituents are transferred most efficiently, and unsymmetric iodonium salts give chemoselective arylations. The methodology has been applied to the formal synthesis of butoxycaine.
Place, publisher, year, edition, pages
2014. Vol. 3, no 2, 54-57 p.
aliphatic alcohols, alkyl aryl ethers, arylation, diaryliodonium salts, hypervalent iodine
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-103962DOI: 10.1002/open.201402006ISI: 000334680800002OAI: oai:DiVA.org:su-103962DiVA: diva2:722868
FunderSwedish Research Council, 621-2011-3608Wenner-Gren Foundations