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Fourth-generation sequencing in the cell and the clinic
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab).
Stockholm University, Faculty of Science, Department of Biochemistry and Biophysics. Stockholm University, Science for Life Laboratory (SciLifeLab).
2014 (English)In: Genome Medicine, ISSN 1756-994X, E-ISSN 1756-994X, Vol. 6, 31- p.Article in journal (Refereed) Published
Abstract [en]

Nearly 40 years ago, DNA was sequenced for the first time. Since then, DNA sequencing has undergone continuous development, passing through three generations of sequencing technology. We are now entering the beginning of a new phase of genomic analysis in which massively parallel sequencing is performed directly in the cell. Two methods have recently been described for in situ RNA sequencing, one targeted and one untargeted, that rely on ligation chemistry. This fourth generation of sequencing technology opens up prospects for transcriptomic analysis, biomarker validation, diagnosis and patient stratification for cancer treatment.

Place, publisher, year, edition, pages
2014. Vol. 6, 31- p.
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Biochemistry and Molecular Biology Genetics
Identifiers
URN: urn:nbn:se:su:diva-104418DOI: 10.1186/gm548ISI: 000335409400001OAI: oai:DiVA.org:su-104418DiVA: diva2:725918
Note

AuthorCount:2;

Available from: 2014-06-17 Created: 2014-06-10 Last updated: 2017-12-05Bibliographically approved

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