Change search
ReferencesLink to record
Permanent link

Direct link
Dosimetric evaluation of manually and inversely optimized treatment planning for high dose rate brachytherapy of cervical cancer
Show others and affiliations
2014 (English)In: Acta Oncologica, ISSN 0284-186X, E-ISSN 1651-226X, Vol. 53, no 8, 1012-1018 p.Article in journal (Refereed) Published
Abstract [en]

Background. To compare five inverse treatment planning methods with the conventional manually optimized planning approach for brachytherapy of cervical cancer with respect to dosimetric parameters.

Material and methods. Eighteen cervical cancer patients treated with magnetic resonance imaging (MRI)-guided high dose rate (HDR) brachytherapy were included in this study. Six plans were created for each of the 4 HDR brachytherapy fractions for each patient: 1 manually optimized and 5 inversely planned. Three of these were based on inverse planning simulated annealing (IPSA) with and without extra constraints on maximum doses of the target volume, and different constraints on doses to the organs at risk (OARs). In addition there were two plans based on dose to target surface points. The resulting dose-volume histograms were analyzed and compared from the dosimetric point of view by quantifying specific dosimetric parameters, such as clinical target volume (CTV) D90, CTV D100, conformal index (COIN), and D2cm3 for rectum, bladder and the sigmoid colon.

Results. Manual optimization led to a mean target coverage of 78.3% compared to 87.5%, 91.7% and 82.5% with the three IPSA approaches (p < 0.001). Similar COIN values for manual and inverse optimization were found. The manual optimization led to better results with respect to the dose to the OARs expressed as D2cm3. Overall, the best results were obtained with manual optimization and IPSA plans with volumetric constraints including maximum doses to the target volume.

Conclusions. Dosimetric evaluation of manual and inverse optimization approaches is indicating the potential of IPSA for brachytherapy of cervical cancer. IPSA with constraints of maximum doses to the target volume is closer related to manual optimization than plans with constraints only to minimum dose to the target volume and maximum doses to OARs. IPSA plans with proper constraints performed better than those based on dose to target surface points and manually optimized plans.

Place, publisher, year, edition, pages
2014. Vol. 53, no 8, 1012-1018 p.
National Category
Cancer and Oncology
URN: urn:nbn:se:su:diva-105722DOI: 10.3109/0284186X.2014.928829ISI: 000340892900004OAI: diva2:730912
Available from: 2014-06-30 Created: 2014-06-30 Last updated: 2014-11-20Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textOpen Access PDF (3070 kB)Supplemental Material

Search in DiVA

By author/editor
Toma-Dasu, Iuliana
By organisation
Department of Physics
In the same journal
Acta Oncologica
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 39 hits
ReferencesLink to record
Permanent link

Direct link