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Editing our way to regeneration
Stockholm University, Faculty of Science, Department of Molecular Biosciences, The Wenner-Gren Institute.
2014 (English)In: Cell and Tissue Research, ISSN 0302-766X, E-ISSN 1432-0878, Vol. 356, no 3, 533-537 p.Article, review/survey (Refereed) Published
Abstract [en]

Transcription is the primary regulatory step to gene expression. However, there are numerous post-transcriptional mechanisms that are also crucial for developing the transcritptome, and the subsequent proteome, signature of any physiological setting. Organ and tissue regeneration is one such physiological setting that requires the rapid development of an environment that can supply all of the necessary molecular and cellular signalling needs necessary to attenuate infection, remove dead or necrotic cells, provide structural stability and finally replenish the compromised area with functional cells. The post-transcriptional regulatory mechanisms that have the ability to heavily influence the molecular and cellular pathways associated with regeneration are slowly being characterized. This mini-review will further clarify the possible regulation of regeneration through adenosine-to-inosine (A-I) RNA editing; a post-transcriptional mechanism that can affect the molecular and cellular pathways associated with functional restoration of damaged tissues and organs through discrete nucleotide changes in RNA transcripts. It is hoped that the intriguing links made between A-I RNA editing and regeneration in this mini-review will encourage further comparative studies into this infant field of research.

Place, publisher, year, edition, pages
2014. Vol. 356, no 3, 533-537 p.
Keyword [en]
Adenosine-to-inosine RNA editing, Newt, Post-transcriptional regulation, Regeneration, Stem Cells
National Category
Cell Biology
URN: urn:nbn:se:su:diva-105902DOI: 10.1007/s00441-014-1844-6ISI: 000336615200008OAI: diva2:733368


Available from: 2014-07-09 Created: 2014-07-08 Last updated: 2014-07-09Bibliographically approved

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