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Dried saliva spot as a sampling technique for saliva samples
Stockholm University, Faculty of Science, Department of Analytical Chemistry.
2014 (English)In: BMC Biomedical chromotography, ISSN 0269-3879, E-ISSN 1099-0801, Vol. 28, no 6, 875-877 p.Article in journal (Refereed) Published
Abstract [en]

For the first time, dried saliva spot (DSS) was used as a sampling technique for saliva samples. In the DSS technique 50 L of saliva was collected on filter paper and the saliva was then extracted with an organic solvent. The local anesthetic lidocaine was used as a model compound, which was determined in the DSS using liquid chromatography and mass spectrometry. The results obtained for the determination of lidocaine in saliva using DSS were compared with those from a previous study using a microextraction by packed sorbent syringe as the sampling method for saliva. This study shows that DSS can be used for the analysis of saliva samples. The method is promising and very easy in terms of sampling and extraction procedures. The results from this study are in good agreement with those from our previous work on the determination of lidocaine in saliva. DSS can open a new dimension in the saliva handling process in terms of sampling, storing and transport.

Place, publisher, year, edition, pages
2014. Vol. 28, no 6, 875-877 p.
Keyword [en]
saliva, dried saliva spot, lidocaine, LC/MS/MS
National Category
Analytical Chemistry
URN: urn:nbn:se:su:diva-106078DOI: 10.1002/bmc.3193ISI: 000337531900023OAI: diva2:735573


Available from: 2014-07-29 Created: 2014-07-21 Last updated: 2014-07-29Bibliographically approved

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Abdel-Rehim, Mohamed
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