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Microextraction by packed sorbent: an emerging, selective and high-throughput extraction technique in bioanalysis
Stockholm University, Faculty of Science, Department of Analytical Chemistry.
Stockholm University, Faculty of Science, Department of Analytical Chemistry. National Research Center, Egypt.
2014 (English)In: BMC Biomedical chromotography, ISSN 0269-3879, E-ISSN 1099-0801, Vol. 28, no 6, 839-847 p.Article in journal (Refereed) Published
Abstract [en]

Sample preparation is an important analytical step regarding the isolation and concentration of desired components from complex matrices and greatly influences their reliable and accurate analysis and data quality. It is the most labor-intensive and error-prone process in analytical methodology and, therefore, may influence the analytical performance of the target analytes quantification. Many conventional sample preparation methods are relatively complicated, involving time-consuming procedures and requiring large volumes of organic solvents. Recent trends in sample preparation include miniaturization, automation, high-throughput performance, on-line coupling with analytical instruments and low-cost operation through extremely low volume or no solvent consumption. Micro-extraction techniques, such as micro-extraction by packed sorbent (MEPS), have these advantages over the traditional techniques. This paper gives an overview of MEPS technique, including the role of sample preparation in bioanalysis, the MEPS description namely MEPS formats (on- and off-line), sorbents, experimental and protocols, factors that affect the MEPS performance, and the major advantages and limitations of MEPS compared with other sample preparation techniques. We also summarize MEPS recent applications in bioanalysis.

Place, publisher, year, edition, pages
2014. Vol. 28, no 6, 839-847 p.
Keyword [en]
micro-extraction techniques (ET), micro-extraction by packed sorbent (MEPS), sorbents, applications, future trends
National Category
Analytical Chemistry
URN: urn:nbn:se:su:diva-106077DOI: 10.1002/bmc.3156ISI: 000337531900018OAI: diva2:735575


Available from: 2014-07-29 Created: 2014-07-21 Last updated: 2014-07-29Bibliographically approved

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Colmsjö, AndersAbdel-Rehim, Mohamed
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