Observation of correlated X-ray scattering at atomic resolution
2014 (English)In: Philosophical Transactions of the Royal Society of London. Biological Sciences, ISSN 0962-8436, Vol. 369, no 1647, 20130315- p.Article in journal (Refereed) Published
Tools to study disordered systems with local structural order, such as proteins in solution, remain limited. Such understanding is essential for e. g. rational drug design. Correlated X-ray scattering (CXS) has recently attracted new interest as a way to leverage next-generation light sources to study such disordered matter. The CXS experiment measures angular correlations of the intensity caused by the scattering of X-rays from an ensemble of identical particles, with disordered orientation and position. Averaging over 15 496 snapshot images obtained by exposing a sample of silver nanoparticles in solution to a micro-focused synchrotron radiation beam, we report on experimental efforts to obtain CXS signal from an ensemble in three dimensions. A correlation function was measured at wide angles corresponding to atomic resolution that matches theoretical predictions. These preliminary results suggest that other CXS experiments on disordered ensembles-such as proteins in solution-may be feasible in the future.
Place, publisher, year, edition, pages
2014. Vol. 369, no 1647, 20130315- p.
X-ray angular correlations, Bragg peak correlations, silver nanoparticles, atomic resolution X-ray scattering, synchrotron radiation, solution ensemble
IdentifiersURN: urn:nbn:se:su:diva-106184DOI: 10.1098/rstb.2013.0315ISI: 000337367600005OAI: oai:DiVA.org:su-106184DiVA: diva2:735607