Change search
ReferencesLink to record
Permanent link

Direct link
Synthesis and biological evaluation of some new triazolo[1,5-a]quinoline derivatives as anticancer and antimicrobial agents
Show others and affiliations
Number of Authors: 6
2014 (English)In: RSC Advances, ISSN 2046-2069, Vol. 4, no 46, 24131-24141 p.Article in journal (Refereed) Published
Abstract [en]

In the present study, versatile multifunctional unreported triazolo[1,5-a]quinoline derivatives were prepared. Compounds 1-19 were synthesized by adopting appropriate synthetic routes and were pharmacologically evaluated for their in vitro anticancer activity against human cancer cell lines: hepatocellular liver carcinoma (HEPG2) and Caucasian breast adenocarcinoma (MCF-7), in addition to their antibacterial and antifungal activities. Compound 4 demonstrated strong inhibitory effects against breast cancer (MCF-7), whereas compounds 8 and 19 exhibited moderate activity against breast carcinoma cell line MCF-7. Compounds 16 and 19 gave moderate activity against liver carcinoma cell line HEPG2. The antimicrobial activity of the prepared compounds was tested against bacteria and fungi. Among them, the results of antimicrobial activity indicated that compounds 4, 9, 11, 13, 15, 17, 18 and 19 were the most active compounds. Compound 4 exhibited strong activity against Fusarium sp., whereas compounds 9, 11, 15, 17, 18 and 19 showed high activity against Escherichia coli. More specifically, compound 17 displayed a high inhibitory effect against Bacillus cereus, Escherichia coli and Rhizoctonia sp.

Place, publisher, year, edition, pages
2014. Vol. 4, no 46, 24131-24141 p.
National Category
Chemical Sciences
URN: urn:nbn:se:su:diva-106458DOI: 10.1039/c3ra46961aISI: 000338042500028OAI: diva2:736115


Available from: 2014-08-05 Created: 2014-08-04 Last updated: 2014-08-05Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Rehim, Mohamed Abdel
By organisation
Department of Analytical Chemistry
In the same journal
RSC Advances
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 36 hits
ReferencesLink to record
Permanent link

Direct link