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Brominated Flame Retardants in Matched Serum Samples from Swedish First-Time Mothers and Their Toddlers
Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
Stockholm University, Faculty of Science, Department of Applied Environmental Science (ITM).
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2014 (English)In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 48, no 13, 7584-7592 p.Article in journal (Refereed) Published
Abstract [en]

Tri-decabrominated diphenyl ethers and 21 other flame retardants were determined in matched serum samples from 24 Swedish mothers (Uppsala county) and their toddlers (11-15 months of age). The median concentrations of individual polybrominated diphenyl ethers (PBDEs) ranged from 0.036 to 0.95 ng/g lipid in mothers and from 0.057 to 1.5 ng/g lipid in toddlers. BDE-209 was detected in all but one sample. BDE-153 was the predominant congener in the mothers while in toddlers, BDE-209 was found in the highest concentrations. The levels of BDE-47, -100, -207, -208, and -209 in toddlers were significantly higher (p < 0.05) than those in their mothers. Dechlorane Plus (anti- and syn-) and alpha- and beta-tetrabromoethylcyclohexane were detected in a few (2-4) serum samples from both mothers and toddlers. This study also reports concentrations of alpha-HBCD and eight emerging brominated flame retardants (EBFRs) in the standard reference material serum (SRM 1958, NIST). Lack of correlations between the matched serum samples indicate different exposure routes for octa-decaBDEs in mothers versus toddlers. Congener-to-congener correlations within the mother or toddler cohorts suggest diet as an important exposure pathway for tetra-nonaBDEs for mothers, breastfeeding as a predominant exposure pathway for tetra-hexaBDEs, and dust for octa-decaBDEs for toddlers.

Place, publisher, year, edition, pages
2014. Vol. 48, no 13, 7584-7592 p.
National Category
Earth and Related Environmental Sciences
Research subject
Applied Environmental Science
Identifiers
URN: urn:nbn:se:su:diva-106581DOI: 10.1021/es501139dISI: 000338488700049OAI: oai:DiVA.org:su-106581DiVA: diva2:737918
Note

AuthorCount:5;

Available from: 2014-08-14 Created: 2014-08-12 Last updated: 2017-12-05Bibliographically approved
In thesis
1. Linking exposure pathways to internal concentrations of brominated flame retardants in Swedish mothers and their toddlers
Open this publication in new window or tab >>Linking exposure pathways to internal concentrations of brominated flame retardants in Swedish mothers and their toddlers
2014 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Brominated flame retardants (BFRs) have been used in a variety of consumer products to enhance their fire safety. This has resulted in exposure of the environment, wildlife and humans causing risks of endocrine disruption. The use restrictions of many BFRs have resulted in the introduction of other brominated chemicals (emerging BFRs) on the market. Humans are exposed to BFRs primarily via diet and dust ingestion, but the importance of the different exposure pathways has scarcely been studied. Children in particular have not been studied well due to lack of biomonitoring data.

In this thesis, a mother-toddler cohort (n=24) from Uppsala was studied for their exposure to tri-decabrominated diphenyl ethers (tri-decaBDEs), isomer-specific hexabromocyclododecanes (HBCDs) and emerging BFRs (EBFRs). A clean-up and fractionation method was developed for determination of the above-mentioned BFRs in the same sample without dividing the sample. Measures of external exposure from dietary intake and dust ingestion were estimated. These were compared to internal concentrations (serum, feces) to determine which exposure pathways were most important for explaining the different BFR concentrations and patterns found in mothers and toddlers.

Taking all the results into account, the toddlers’ higher serum levels of tetra-pentaBDEs seem to be the result of previous breastfeeding and those of octa-decaBDEs from exposure to house dust. For mothers, diet was estimated to be the main exposure route of tri-hexaBDEs and HBCDs. Dust ingestion was estimated to be the main route for BDE-209 exposure in mothers.

Significant correlations were found between the tetra-decaBDE concentrations in matched serum and feces samples indicating that feces could be used as a non-invasive sample matrix for biomonitoring of PBDEs in toddlers. EBFRs were detected in the feces of toddlers and in a few serum samples from both mothers and toddlers indicating that exposure to these replacement chemicals occurs.

Place, publisher, year, edition, pages
Stockholm: Department of Applied Environmental Science, Stockholm University, 2014. 35 p.
Keyword
BFR, PBDE, HBCD, EBFR, human exposure, serum, feces, house dust, food
National Category
Environmental Sciences
Research subject
Applied Environmental Science
Identifiers
urn:nbn:se:su:diva-107592 (URN)978-91-7649-000-6 (ISBN)
Public defence
2014-11-07, De Geersalen, Geovetenskapens hus, Svante Arrhenius väg 14, Stockholm, 09:00 (English)
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Supervisors
Note

 At the time of the doctoral defense, the following papers were unpublished and had a status as follows: Paper 3: Submitted. Paper 4: Manuscript.

Available from: 2014-10-16 Created: 2014-09-22 Last updated: 2014-11-18Bibliographically approved

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