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Diagnostic and Prognostic Value of Soluble Syndecan-1 in Pleural Malignancies
Stockholm University, Faculty of Social Sciences, Stress Research Institute. Karolinska Institutet, Sweden.
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2014 (English)In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, 419853- p.Article in journal (Refereed) Published
Abstract [en]

Background. The distinction between malignant and benign pleural effusions is a diagnostic challenge today and measuring soluble biomarkers could add to the diagnostic accuracy. Syndecan-1 is a proteoglycan involved in various cellular functions and is cleaved from the cell surface in a regulated manner. The shed fragment, which can be recovered in effusion supernatant and in serum, retains its binding capacities, but often with different functions and signalling properties than the cell-bound form. Aim. This study aimed to investigate the diagnostic and prognostic value of soluble syndecan-1 in pleural effusions and sera from patients with pleural malignancies. Study Design. Using two cohorts of patients, we assessed the diagnostic and prognostic value of soluble syndecan-1 in pleural effusions and sera, using enzyme-linked immunosorbent assays. Results. In pleural effusions, syndecan-1 distinguished malignant and benign diseases, with an odds ratio of 8.59 (95% CI 3.67 to 20.09). Furthermore, syndecan-1 in pleural effusions predicted a survival difference for patients with pleural metastatic disease and malignant mesothelioma of 11.2 and 9.2 months, respectively. However, no such effects were seen when syndecan-1 was measured in serum. Conclusion. Soluble syndecan-1 is a promising candidate biomarker for the cytopathological diagnosis and prognostication of malignant pleural effusions.

Place, publisher, year, edition, pages
2014. 419853- p.
National Category
Psychology Neurosciences
URN: urn:nbn:se:su:diva-107199DOI: 10.1155/2014/419853ISI: 000340134100001Local ID: P-3175OAI: diva2:744243


Available from: 2014-09-08 Created: 2014-09-05 Last updated: 2014-11-20Bibliographically approved

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Nilsonne, Gustav
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Stress Research Institute
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