Open this publication in new window or tab >>2018 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]
Today’s society has a large demand for biologically active chemicals that can be used for example as pharmaceuticals and in the agriculture. These are normally constructed by assembling together several smaller chemical molecules. In order to achieve this, we need that these small molecules contain certain reactive sites, or in other words, that they are functionalized with certain atoms. The work in this thesis investigates and develops new methods to create functionalities in molecules, which in turn can be used to construct larger compounds and other materials important for our society.
The methods herein developed are based on the use of metal catalysts to construct carbon-halogen bonds. Examples of halogens include bromide and iodide. When a molecule contains one (or more) of these bonds, it can be transformed in a simple chemical step into other compounds. The number of possible chemical transformations becomes almost endless. Thus, by accessing these compounds, chemical libraries can be created easily.
Throughout the work, sustainability has been prioritized by using, for the human health, friendly solvents whenever possible, by using versatile, stable and structurally simple but yet effective catalysts, and by minimizing the need to use unnecessary chemical activators.
Place, publisher, year, edition, pages
Stockholm: Department of Organic Chemistry, Stockholm University, 2018. p. 68
Keywords
Iridium Catalysis, Method development, Halogenation, Isomerization, C-H Activation
National Category
Organic Chemistry
Research subject
Organic Chemistry
Identifiers
urn:nbn:se:su:diva-161412 (URN)978-91-7797-486-4 (ISBN)978-91-7797-487-1 (ISBN)
Public defence
2018-12-10, Magnélisalen, Kemiska övningslaboratoriet, Svante Arrhenius väg 16 B, Stockholm, 10:00 (English)
Opponent
Supervisors
Note
At the time of the doctoral defense, the following paper was unpublished and had a status as follows: Paper 4: Manuscript.
2018-11-152018-10-242022-02-26Bibliographically approved