Enantioselective Heterogeneous Synergistic Catalysis for Asymmetric Cascade Transformations
2014 (English)In: Advanced Synthesis and Catalysis, ISSN 1615-4150, E-ISSN 1615-4169, Vol. 356, no 11-12, 2485-2492 p.Article in journal (Refereed) Published
A modular design for a novel heterogeneous synergistic catalytic system, which simultaneously activates the electrophile and nucleophile by the combined activation modes of a separate metal and non-metal catalyst, for asymmetric cascade transformations on a solid surface is disclosed. This modular catalysis strategy generates carbocycles (up to 97.5: 2.5 er) as well as spirocyclic oxindoles (97.5: 2.5 to > 99: 0.5 er), containing all-carbon quaternary centers, in a highly enantioselective fashion via a one-pot dynamic relay process.
Place, publisher, year, edition, pages
2014. Vol. 356, no 11-12, 2485-2492 p.
all-carbon quaternary stereocenters, carbocycles, co-catalysis, dynamic transformations, heterogeneous synergistic catalysis
Research subject Organic Chemistry
IdentifiersURN: urn:nbn:se:su:diva-107625DOI: 10.1002/adsc.201400291ISI: 000340567100014OAI: oai:DiVA.org:su-107625DiVA: diva2:749423
FunderSwedish Research CouncilVINNOVA