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Re-Evaluation of Clinical Dementia Diagnoses with Pittsburgh Compound B Positron Emission Tomography
Stockholm University, Faculty of Social Sciences, Department of Psychology.
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2013 (English)In: Dementia and geriatric cognitive disorders extra, E-ISSN 1664-5464, Vol. 3, no 1, 472-481 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: There is an overlap regarding Pittsburgh compound B (PIB) retention in patients clinically diagnosed as Alzheimer's disease (AD) and non-AD dementia. The aim of the present study was to investigate whether there are any differences between PIB-positive and PIB-negative patients in a mixed cohort of patients with neurodegenerative dementia of mild severity regarding neuropsychological test performance and regional cerebral glucose metabolism measured with [18F]fluoro-2-deoxy-d-glucose (FDG) positron emission tomography (PET). Methods: Eighteen patients clinically diagnosed as probable AD or frontotemporal dementia were examined with PIB PET, FDG PET and neuropsychological tests and followed for 5-9 years in a clinical setting. Results: The PIB-positive patients (7 out of 18) had slower psychomotor speed and more impaired visual episodic memory than the PIB-negative patients; otherwise performance did not differ between the groups. The initial clinical diagnoses were changed in one third of the patients (6 out of 18) during follow-up. Conclusions: The subtle differences in neuropsychological performance, the overlap of hypometabolic patterns and clinical features between AD and non-AD dementia highlight the need for amyloid biomarkers and a readiness to re-evaluate the initial diagnosis.

Place, publisher, year, edition, pages
Basel: S. Karger, 2013. Vol. 3, no 1, 472-481 p.
Keyword [en]
Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, Amyloid biomarker, positron emission tomography, neuropsychological tests, Trail Making Test, episodic memory
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URN: urn:nbn:se:su:diva-108401DOI: 10.1159/000356273OAI: diva2:757508

This study was supported by grants from the Alzheimer's Association and Amersham Foundation. The authors thank the research nurse Christina Alm for assistance in the study.

Available from: 2014-10-22 Created: 2014-10-22 Last updated: 2014-10-23Bibliographically approved

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Lindau, Maria
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